Patient characteristics (N = 126)
| Characteristic . | Category . | N . | % . |
|---|---|---|---|
| Sex | Male | 93 | 74 |
| Female | 33 | 26 | |
| Age | Median: 33 y (18-81 y) | ||
| 15-25 y | 35 | 28 | |
| 26-55 y | 72 | 59 | |
| > 55 y | 16 | 13 | |
| Initial diagnosis | T-ALL | 107 | 85 |
| T-LBL | 19 | 15 | |
| Phenotype* (N = 93) | Early | 36 | 39 |
| Thymic | 45 | 48 | |
| Mature | 10 | 11 | |
| Biphenotypic† | 2 | 2 | |
| Disease status at study entry | Primary refractory | 13 | 10 |
| First relapse on chemotherapy | 73 | 58 | |
| Second relapse on chemotherapy | 13 | 10 | |
| Relapse after SCT | 27 | 21 | |
| Type of involvement | Bone marrow only | 83 | 66 |
| Extramedullary only | 22 | 17 | |
| Both | 21 | 17 | |
| BM infiltration (N = 97) | Median: 70% (6-98) | ||
| Type of extramedullary involvement (N = 44) | Mediastinal tumor ± pleural effusion | 24 | 19 |
| Pleural effusion only | 4 | 3 | |
| Lymph nodes | 5 | 4 | |
| Skin | 4 | 3 | |
| Mamma | 3 | 2 | |
| Other | 3 | 2 |
| Characteristic . | Category . | N . | % . |
|---|---|---|---|
| Sex | Male | 93 | 74 |
| Female | 33 | 26 | |
| Age | Median: 33 y (18-81 y) | ||
| 15-25 y | 35 | 28 | |
| 26-55 y | 72 | 59 | |
| > 55 y | 16 | 13 | |
| Initial diagnosis | T-ALL | 107 | 85 |
| T-LBL | 19 | 15 | |
| Phenotype* (N = 93) | Early | 36 | 39 |
| Thymic | 45 | 48 | |
| Mature | 10 | 11 | |
| Biphenotypic† | 2 | 2 | |
| Disease status at study entry | Primary refractory | 13 | 10 |
| First relapse on chemotherapy | 73 | 58 | |
| Second relapse on chemotherapy | 13 | 10 | |
| Relapse after SCT | 27 | 21 | |
| Type of involvement | Bone marrow only | 83 | 66 |
| Extramedullary only | 22 | 17 | |
| Both | 21 | 17 | |
| BM infiltration (N = 97) | Median: 70% (6-98) | ||
| Type of extramedullary involvement (N = 44) | Mediastinal tumor ± pleural effusion | 24 | 19 |
| Pleural effusion only | 4 | 3 | |
| Lymph nodes | 5 | 4 | |
| Skin | 4 | 3 | |
| Mamma | 3 | 2 | |
| Other | 3 | 2 |