Characteristics of cGVHD patients and response to ECP therapy
| Organ affected by cGVHD at ECP start . | Pre-ECP, (n = 46) . | Response after 3 mo of ECP, % (n = 46) . | Response after 6 mo of ECP,* % (n = 39) . | ||||
|---|---|---|---|---|---|---|---|
| CR . | PR . | Nonresponse . | CR . | PR . | Nonresponse . | ||
| Skin, n (%) | 35 (76) | 12 (34) | 13 (37) | 10 (29) | 12 (42) | 3 (10) | 14 (48) |
| Liver, n (%) | 24 (52) | 2 (8) | 9 (38) | 13 (54) | 2 (10) | 7 (36) | 11 (55) |
| Ocular, n (%) | 23 (50) | 6 (26) | 5 (22) | 12 (52) | 4 (21) | 6 (32) | 9 (47) |
| Gut, n (%) | 12 (26) | 5 (42) | 5 (42) | 2 (17) | 6 (60) | 1 (10) | 3 (30) |
| Mucous membrane, n (%) | 11 (23) | 3 (27) | 4 (36) | 4 (36) | 6 (60) | 1 (10) | 3 (30) |
| Lungs, n (%) † | 10 (21) | 1 (10) | 1 (10) | 6 (60) | 1 (10) | 0 (0) | 6 (60) |
| Genital, n (%) | 3 (6) | 0 (0) | 3 (100) | 0 (0) | 0 (0) | 2 (100) | 0 (0) |
| Organ affected by cGVHD at ECP start . | Pre-ECP, (n = 46) . | Response after 3 mo of ECP, % (n = 46) . | Response after 6 mo of ECP,* % (n = 39) . | ||||
|---|---|---|---|---|---|---|---|
| CR . | PR . | Nonresponse . | CR . | PR . | Nonresponse . | ||
| Skin, n (%) | 35 (76) | 12 (34) | 13 (37) | 10 (29) | 12 (42) | 3 (10) | 14 (48) |
| Liver, n (%) | 24 (52) | 2 (8) | 9 (38) | 13 (54) | 2 (10) | 7 (36) | 11 (55) |
| Ocular, n (%) | 23 (50) | 6 (26) | 5 (22) | 12 (52) | 4 (21) | 6 (32) | 9 (47) |
| Gut, n (%) | 12 (26) | 5 (42) | 5 (42) | 2 (17) | 6 (60) | 1 (10) | 3 (30) |
| Mucous membrane, n (%) | 11 (23) | 3 (27) | 4 (36) | 4 (36) | 6 (60) | 1 (10) | 3 (30) |
| Lungs, n (%) † | 10 (21) | 1 (10) | 1 (10) | 6 (60) | 1 (10) | 0 (0) | 6 (60) |
| Genital, n (%) | 3 (6) | 0 (0) | 3 (100) | 0 (0) | 0 (0) | 2 (100) | 0 (0) |
Seven patients halted treatment between 3 and 6 months: 3 died of progressive disease and concurrent infection and were regarded as nonresponders, 1 missed treatments because of infection, 2 had disease relapse, and 1 patient lost venous access. A total of 37 of 39 patients continued ECP therapy beyond 6 months.
Two patients had missing lung function data at 3 and 6 months.