Other (nonhematologic/noninfectious) toxicity
| Toxicity* . | Grade 1 or 2 . | Grade 3 or 4 . | ||
|---|---|---|---|---|
| No. of patients . | % of patients . | No. of patients . | % of patients . | |
| Fatigue | 55 | 92 | 2 | 3 |
| Diarrhea | 33 | 55 | 0 | 0 |
| Constipation | 33 | 55 | 1 | 2 |
| Tumor flare | 31 | 52 | 0 | 0 |
| Skin rash | 29 | 48 | 1 | 2 |
| Sweating | 29 | 48 | 0 | 0 |
| Pruritus | 26 | 43 | 2 | 3 |
| Cough | 24 | 40 | 0 | 0 |
| Nausea or vomiting | 23 | 38 | 0 | 0 |
| Dyspnea | 20 | 33 | 1 | 2 |
| Joint pains | 18 | 30 | 0 | 0 |
| Dizziness or syncope | 16 | 27 | 1 | 2 |
| Hyperglycemia | 18 | 30 | 1 | 2 |
| Creatinine | 15 | 25 | 0 | 0 |
| Fever, non-neutropenic | 14 | 23 | 1 | 2 |
| Dry mouth | 13 | 22 | 0 | 0 |
| Decreased appetite | 14 | 23 | 1 | 2 |
| Dry skin | 14 | 23 | 0 | 0 |
| Sensory neuropathy | 13 | 22 | 0 | 0 |
| Back pain | 13 | 22 | 0 | 0 |
| Hypomagnesemia | 12 | 20 | 0 | 0 |
| Neurologic NOS | 12 | 20 | 0 | 0 |
| Muscular pain | 12 | 20 | 0 | 0 |
| Insomnia | 12 | 20 | 0 | 0 |
| Abdominal pain NOS | 11 | 18 | 2 | 3 |
| Hyperuricemia | 10 | 17 | 0 | 0 |
| Abnormal ALT or AST | 10 | 17 | 2 | 3 |
| Hyperkalemia | 9 | 15 | 1 | 2 |
| Headache | 9 | 15 | 1 | 2 |
| Flatulence | 9 | 15 | 0 | 0 |
| Hypocalcemia | 8 | 13 | 0 | 0 |
| Heartburn | 8 | 13 | 0 | 0 |
| Skin, other lesions | 8 | 13 | 0 | 0 |
| Peripheral edema | 8 | 13 | 0 | 0 |
| Bloating/abdominal distension | 8 | 13 | 0 | 0 |
| Gastrointestinal, NOS | 7 | 12 | 1 | 2 |
| Hyperbilirubinemia | 7 | 12 | 2 | 3 |
| Weight loss | 7 | 12 | 0 | 0 |
| Muscle cramps | 6 | 10 | 0 | 0 |
| Hypokalemia | 4 | 7 | 4 | 7 |
| Toxicity* . | Grade 1 or 2 . | Grade 3 or 4 . | ||
|---|---|---|---|---|
| No. of patients . | % of patients . | No. of patients . | % of patients . | |
| Fatigue | 55 | 92 | 2 | 3 |
| Diarrhea | 33 | 55 | 0 | 0 |
| Constipation | 33 | 55 | 1 | 2 |
| Tumor flare | 31 | 52 | 0 | 0 |
| Skin rash | 29 | 48 | 1 | 2 |
| Sweating | 29 | 48 | 0 | 0 |
| Pruritus | 26 | 43 | 2 | 3 |
| Cough | 24 | 40 | 0 | 0 |
| Nausea or vomiting | 23 | 38 | 0 | 0 |
| Dyspnea | 20 | 33 | 1 | 2 |
| Joint pains | 18 | 30 | 0 | 0 |
| Dizziness or syncope | 16 | 27 | 1 | 2 |
| Hyperglycemia | 18 | 30 | 1 | 2 |
| Creatinine | 15 | 25 | 0 | 0 |
| Fever, non-neutropenic | 14 | 23 | 1 | 2 |
| Dry mouth | 13 | 22 | 0 | 0 |
| Decreased appetite | 14 | 23 | 1 | 2 |
| Dry skin | 14 | 23 | 0 | 0 |
| Sensory neuropathy | 13 | 22 | 0 | 0 |
| Back pain | 13 | 22 | 0 | 0 |
| Hypomagnesemia | 12 | 20 | 0 | 0 |
| Neurologic NOS | 12 | 20 | 0 | 0 |
| Muscular pain | 12 | 20 | 0 | 0 |
| Insomnia | 12 | 20 | 0 | 0 |
| Abdominal pain NOS | 11 | 18 | 2 | 3 |
| Hyperuricemia | 10 | 17 | 0 | 0 |
| Abnormal ALT or AST | 10 | 17 | 2 | 3 |
| Hyperkalemia | 9 | 15 | 1 | 2 |
| Headache | 9 | 15 | 1 | 2 |
| Flatulence | 9 | 15 | 0 | 0 |
| Hypocalcemia | 8 | 13 | 0 | 0 |
| Heartburn | 8 | 13 | 0 | 0 |
| Skin, other lesions | 8 | 13 | 0 | 0 |
| Peripheral edema | 8 | 13 | 0 | 0 |
| Bloating/abdominal distension | 8 | 13 | 0 | 0 |
| Gastrointestinal, NOS | 7 | 12 | 1 | 2 |
| Hyperbilirubinemia | 7 | 12 | 2 | 3 |
| Weight loss | 7 | 12 | 0 | 0 |
| Muscle cramps | 6 | 10 | 0 | 0 |
| Hypokalemia | 4 | 7 | 4 | 7 |
NOS indicates not otherwise specified; ALT, alanine transaminase; and AST, aspartate aminotransferase.
Toxicity listed if any grade 3 or 4, or grade 1 or 2 in ≥ 10% of patients.