Atp4asublytic/− mice develop hypochromic microcytic anemia
| Strain . | RBCs, 106/μL . | HGB, g/dL* . | HCT, %* . | MCV, fl* . | MCH, pg* . | MCHC, g/dL* . | RDW, %* . |
|---|---|---|---|---|---|---|---|
| Atp4asubltyic/− (n = 5) | 8.7 ± 0.3 | 10.4 ± 1.5 | 33.2 ± 1.7 | 38.0 ± 0.8 | 12.0 ± 0.9 | 31.5 ± 2.9 | 20.8 ± 0.7 |
| Atp4asubltyic/+ (n = 2) | 8.8 ± 0.9 | 13.6 ± 0.9 | 42.4 ± 2.5 | 48.5 ± 2.1 | 15.5 ± 0.4 | 32.0 ± 0.4 | 18.1 ± 0.4 |
| C57BL/6J (n = 3) | 9.9 ± 0.1 | 15.0 ± 0.1 | 46.0 ± 0.2 | 46.7 ± 0.6 | 15.1 ± 0.3 | 32.5 ± 0.4 | 16.9 ± 1.1 |
| sublytic (n = 4) | 7.6 ± 0.4 | 9.1 ± 0.6 | 29.4 ± 1.4 | 39.0 ± 0.8 | 12.0 ± 0.1 | 30.8 ± 0.6 | 20.8 ± 1.1 |
| Strain . | RBCs, 106/μL . | HGB, g/dL* . | HCT, %* . | MCV, fl* . | MCH, pg* . | MCHC, g/dL* . | RDW, %* . |
|---|---|---|---|---|---|---|---|
| Atp4asubltyic/− (n = 5) | 8.7 ± 0.3 | 10.4 ± 1.5 | 33.2 ± 1.7 | 38.0 ± 0.8 | 12.0 ± 0.9 | 31.5 ± 2.9 | 20.8 ± 0.7 |
| Atp4asubltyic/+ (n = 2) | 8.8 ± 0.9 | 13.6 ± 0.9 | 42.4 ± 2.5 | 48.5 ± 2.1 | 15.5 ± 0.4 | 32.0 ± 0.4 | 18.1 ± 0.4 |
| C57BL/6J (n = 3) | 9.9 ± 0.1 | 15.0 ± 0.1 | 46.0 ± 0.2 | 46.7 ± 0.6 | 15.1 ± 0.3 | 32.5 ± 0.4 | 16.9 ± 1.1 |
| sublytic (n = 4) | 7.6 ± 0.4 | 9.1 ± 0.6 | 29.4 ± 1.4 | 39.0 ± 0.8 | 12.0 ± 0.1 | 30.8 ± 0.6 | 20.8 ± 1.1 |
Offspring from female Atp4a+/− and male Atp4asublytic/sublytic mice were subjected to automated CBC analysis. C57BL/6J control mice were analyzed in the same experiment. sublytic homozygotes were analyzed in a separate experiment and are presented here as a reference. All mice were analyzed at 4 weeks of age. Results are presented as means ± SD.
HGB indicates hemoglobin; HCT, hematocrit; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; and RDW, RBC distribution width.
P < .05 (Student t test) for comparisons between Atp4asublytic/− and C57BL/6J mice.