Hematologic parameters in bone marrow transplanted animals
| . | Hb, g/dL . | RBC, ×106/μL . | Hct, % . | MCV, fL . | MCH, pg . | Retic, ×109/L . | LIC, μg/mg dry . | SIC, μg/mg dry . | SI, μg/dL . | Tf Sat, % . |
|---|---|---|---|---|---|---|---|---|---|---|
| Wt → wt | 14.3 ± 0.2 | 10.2 ± 0.2 | 46.6 ± 0.7 | 45.7 ± 0.2 | 14.1 ± 0.1 | 276 ± 12 | 0.29 ± 0.02 | 1.97 ± 0.18 | 117 ± 10 | 56 ± 3 |
| Hfe → Hfe | 15.3 ± 0.2† | 9.7 ± 0.1* | 47.8 ± 0.2 | 49.4 ± 0.8‡ | 15.8 ± 0.1‡ | 238 ± 26 | 0.98 ± 0.08‡ | 2.47 ± 0.75 | 225 ± 13‡ | 88 ± 2† |
| th3/+ → wt | 7.8 ± 0.2 | 8.0 ± 0.2 | 29.2 ± 1.0 | 36.5 ± 1.5 | 9.7 ± 0.1 | 1587 ± 76 | 1.29 ± 0.27 | 8.22 ± 1.12 | 162 ± 11 | 49 ± 4 |
| th3/Hfe → wt | 8.1 ± 0.3 | 8.3 ± 0.2 | 30.8 ± 1.6 | 36.7 ± 1.0 | 9.7 ± 0.2 | 1807 ± 149 | 1.08 ± 0.05 | 10.31 ± 0.74 | 152 ± 12 | 51 ± 3 |
| th3/+ → Hfe | 9.4 ± 0.1‡ | 8.9 ± 0.2† | 36.9 ± 0.3† | 41.6 ± 0.7* | 10.6 ± 0.2† | 1958 ± 102* | 3.09 ± 0.34‡ | 8.29 ± 1.3 | 232 ± 7* | 82 ± 4† |
| . | Hb, g/dL . | RBC, ×106/μL . | Hct, % . | MCV, fL . | MCH, pg . | Retic, ×109/L . | LIC, μg/mg dry . | SIC, μg/mg dry . | SI, μg/dL . | Tf Sat, % . |
|---|---|---|---|---|---|---|---|---|---|---|
| Wt → wt | 14.3 ± 0.2 | 10.2 ± 0.2 | 46.6 ± 0.7 | 45.7 ± 0.2 | 14.1 ± 0.1 | 276 ± 12 | 0.29 ± 0.02 | 1.97 ± 0.18 | 117 ± 10 | 56 ± 3 |
| Hfe → Hfe | 15.3 ± 0.2† | 9.7 ± 0.1* | 47.8 ± 0.2 | 49.4 ± 0.8‡ | 15.8 ± 0.1‡ | 238 ± 26 | 0.98 ± 0.08‡ | 2.47 ± 0.75 | 225 ± 13‡ | 88 ± 2† |
| th3/+ → wt | 7.8 ± 0.2 | 8.0 ± 0.2 | 29.2 ± 1.0 | 36.5 ± 1.5 | 9.7 ± 0.1 | 1587 ± 76 | 1.29 ± 0.27 | 8.22 ± 1.12 | 162 ± 11 | 49 ± 4 |
| th3/Hfe → wt | 8.1 ± 0.3 | 8.3 ± 0.2 | 30.8 ± 1.6 | 36.7 ± 1.0 | 9.7 ± 0.2 | 1807 ± 149 | 1.08 ± 0.05 | 10.31 ± 0.74 | 152 ± 12 | 51 ± 3 |
| th3/+ → Hfe | 9.4 ± 0.1‡ | 8.9 ± 0.2† | 36.9 ± 0.3† | 41.6 ± 0.7* | 10.6 ± 0.2† | 1958 ± 102* | 3.09 ± 0.34‡ | 8.29 ± 1.3 | 232 ± 7* | 82 ± 4† |
Values are mean ± SEM of 5 to 20 female mice.
Hct indicates hematocrit; MCV, mean corpuscular volume; Retic, reticulocyte count; LIC, liver iron concentration; SIC, splenic iron concentration; SI, serum iron; and Tf Sat, transferrin saturation.
P ≤ .05 relative to controls (wt → wt for Hfe → Hfe and th3 → wt for th3/+ → Hfe).
P ≤ .01 relative to controls (wt → wt for Hfe → Hfe and th3 → wt for th3/+ → Hfe).
P ≤ .001 relative to controls (wt → wt for Hfe → Hfe and th3 → wt for th3/+ → Hfe).