Comparative stroke risk in different cohorts
| . | CSSCD . | Jamaica . | Dallas . | London, United Kingdom . | Créteil, France . |
|---|---|---|---|---|---|
| Blood 1998 . | J Pediatr 1992 . | Blood 2004 . | Haematologica 2007 . | Newborn Cohort . | |
| Infant Cohort . | Newborn Cohort . | Newborn Cohort . | Newborn Cohort . | ||
| Enrollment period | 1978-1988 | 1983-2002 | 1983-2005 | 1988-2007 | |
| SS patients | SS patients | SS/Sb0 patients | SS patients | SS/Sb0 patients | |
| Number of patients included in the cohort | 2436 | 310 | 448 | 180 | 217 |
| Patient-years of follow-up | 1781 | 3571 | 1542 | 1609 | |
| Number of first strokes before age 20 years | 51 | 17 | 30 | 7 | 3 |
| First stroke incidence/100 patient-years | 0.61 | ||||
| Up to 16 years | 0.3 (95% CI 0.1-0.8) | ||||
| Up to 18 years | 0.85 | 0.19 (95% CI 0.04-0.5) | |||
| KM estimate of stroke risk by age | |||||
| 4 | 3.7% (95% CI 1.7%-5.7%) | ||||
| 5 | 0.7% (95% CI 0.1%-5.0%) | 1.9% (95% CI 0.6%-5.9%). | |||
| 6 | 5.7% (95% CI 3.3%-8.2%) | ||||
| 10 | 8.4% (95% CI 5.5%-11.6%) | 2.7% (95% CI 0.9%-8.3%) | 1.9% (95% CI 0.6%-5.9%). | ||
| 14 | 7.8% | 11.5% (95% CI 7.3%-15.7%) | 1.9% (95% CI 0.6%-5.9%). | ||
| 15 | 4.3% (95% CI 1.5%-11.4%) | ||||
| 18 | 11.5% (95% CI 7.3%-15.7%) | 1.9% (95% CI 0.6%-5.9%). | |||
| 20 | 11% | 12.8% (95% CI 4.8%-31.3%) |
| . | CSSCD . | Jamaica . | Dallas . | London, United Kingdom . | Créteil, France . |
|---|---|---|---|---|---|
| Blood 1998 . | J Pediatr 1992 . | Blood 2004 . | Haematologica 2007 . | Newborn Cohort . | |
| Infant Cohort . | Newborn Cohort . | Newborn Cohort . | Newborn Cohort . | ||
| Enrollment period | 1978-1988 | 1983-2002 | 1983-2005 | 1988-2007 | |
| SS patients | SS patients | SS/Sb0 patients | SS patients | SS/Sb0 patients | |
| Number of patients included in the cohort | 2436 | 310 | 448 | 180 | 217 |
| Patient-years of follow-up | 1781 | 3571 | 1542 | 1609 | |
| Number of first strokes before age 20 years | 51 | 17 | 30 | 7 | 3 |
| First stroke incidence/100 patient-years | 0.61 | ||||
| Up to 16 years | 0.3 (95% CI 0.1-0.8) | ||||
| Up to 18 years | 0.85 | 0.19 (95% CI 0.04-0.5) | |||
| KM estimate of stroke risk by age | |||||
| 4 | 3.7% (95% CI 1.7%-5.7%) | ||||
| 5 | 0.7% (95% CI 0.1%-5.0%) | 1.9% (95% CI 0.6%-5.9%). | |||
| 6 | 5.7% (95% CI 3.3%-8.2%) | ||||
| 10 | 8.4% (95% CI 5.5%-11.6%) | 2.7% (95% CI 0.9%-8.3%) | 1.9% (95% CI 0.6%-5.9%). | ||
| 14 | 7.8% | 11.5% (95% CI 7.3%-15.7%) | 1.9% (95% CI 0.6%-5.9%). | ||
| 15 | 4.3% (95% CI 1.5%-11.4%) | ||||
| 18 | 11.5% (95% CI 7.3%-15.7%) | 1.9% (95% CI 0.6%-5.9%). | |||
| 20 | 11% | 12.8% (95% CI 4.8%-31.3%) |
CI indicates confidence interval; and CSSCD, Cooperative Study of Sickle Cell Disease.