Effects of sBD1 on thrombus size and TF expression in murine macrophages induced by IgG-APS
| Treatments . | Thrombus size, μm2 . | TF expression in macrophages, AU . |
|---|---|---|
| IgG-APS | 4094.4 ± 1036.8* | 10.1 ± 1.4† |
| IgG-NHS | 287.4 ± 110.0 | 3.2 ± 0.5 |
| IgG-APS + sBD1 | 665.0 ± 173.0 | 4.4 ± 0.6 |
| IgG-NHS + sBD1 | 486.0 ± 164.0 | 3.2 ± 0.7 |
| Dimer | 3757 ± 162‡ | 13.4 ± 3.7§ |
| Monomer | 552.0 ± 79.6 | 3.4 ± 0.8 |
| Dimer + sBD1 | 533 ± 148 | 6.9 ± 1.5 |
| Monomer + sBD1 | 552.0 ± 133.0 | 4.9 ± 1.2 |
| Treatments . | Thrombus size, μm2 . | TF expression in macrophages, AU . |
|---|---|---|
| IgG-APS | 4094.4 ± 1036.8* | 10.1 ± 1.4† |
| IgG-NHS | 287.4 ± 110.0 | 3.2 ± 0.5 |
| IgG-APS + sBD1 | 665.0 ± 173.0 | 4.4 ± 0.6 |
| IgG-NHS + sBD1 | 486.0 ± 164.0 | 3.2 ± 0.7 |
| Dimer | 3757 ± 162‡ | 13.4 ± 3.7§ |
| Monomer | 552.0 ± 79.6 | 3.4 ± 0.8 |
| Dimer + sBD1 | 533 ± 148 | 6.9 ± 1.5 |
| Monomer + sBD1 | 552.0 ± 133.0 | 4.9 ± 1.2 |
AU indicates arbitrary unit; IgG-APS, immunoglobulin G from a patient with antiphospholipid syndrome; IgG-NHS, immunoglobulin G from a patient with normal human serum; sBD1, soluble binding domain 1 of ApoER2; and TF, tissue factor.
Statistically significant from their controls and from sBD1-treated mice; IgG-APS (*P < .0001) and †(P < .0001) or dimer (‡P = .0044) and (§P = .0001).