Substrate specificities of lyases
Lyase . | Glycosidic bond(s) cleaved . | Glycosaminoglycan(s) cleaved . | Reference no. . |
|---|---|---|---|
| Chondroitin ABC-lyase | GalNAc4SO3 and/or 6SO3→UA; GalNAc4SO3→UA2SO3 | C4S, C6S, DS | 40 |
| Chondroitin AC II-lyase | GalNAc4SO3 or 6SO3→GlcA | C4S, C6S, DS* | 41 |
| Chondroitin B-lyase | GalNAc4SO3→IdoA | DS | 42 |
| Flavobacterium heparitinase I | GlcNAc6SO3→UA; GlcNSO3→UA; GlcNSO36SO3→UA | HS | 43 |
Lyase . | Glycosidic bond(s) cleaved . | Glycosaminoglycan(s) cleaved . | Reference no. . |
|---|---|---|---|
| Chondroitin ABC-lyase | GalNAc4SO3 and/or 6SO3→UA; GalNAc4SO3→UA2SO3 | C4S, C6S, DS | 40 |
| Chondroitin AC II-lyase | GalNAc4SO3 or 6SO3→GlcA | C4S, C6S, DS* | 41 |
| Chondroitin B-lyase | GalNAc4SO3→IdoA | DS | 42 |
| Flavobacterium heparitinase I | GlcNAc6SO3→UA; GlcNSO3→UA; GlcNSO36SO3→UA | HS | 43 |
GalNAc indicates N-acetylgalactosamine; UA, hexuronic acid; GlcA, glucuronic acid; IdoA, iduronic acid; GlcNAc, N-acetylglucosamine; GlcNSO3, N-sulfoglucosamine; C4S, chondroitin 4-sulfate; C6S, chondroitin 6-sulfate; DS, dermatan sulfate; and HS, heparan sulfate.
Chondroitin AC II-lyase may cleave some linkages in DS that contain GlcA residues.