Table 4. CD25 CD4 T cells suppress... | American Society of Hematology

Table 4.

CD25⁺CD4⁺ T cells suppress autoantibody production in chronic GVHD BALB/c recipients on day 15 after donor-cell injection

Donor cells	Total IgG1, μg/mL	Total IgG2a, μg/mL	Anti-dsDNA IgG1, U/mL	Anti-dsDNA IgG2a, U/mL	Anti-dsDNA IgG2a^a, U/mL
CD4^–-SPL^* + CD25^–CD4⁺ T†	1678 ± 207	2119 ± 218	1464 ± 239	700 ± 79	<10
CD4^–SPL + CD25^–CD4⁺ T + CD25⁺CD4⁺ T‡	1279 ± 149	1994 ± 166	1097 ± 167	308 ± 38	<10

Donor cells	Total IgG1, μg/mL	Total IgG2a, μg/mL	Anti-dsDNA IgG1, U/mL	Anti-dsDNA IgG2a, U/mL	Anti-dsDNA IgG2a^a, U/mL
CD4^–-SPL^* + CD25^–CD4⁺ T†	1678 ± 207	2119 ± 218	1464 ± 239	700 ± 79	<10
CD4^–SPL + CD25^–CD4⁺ T + CD25⁺CD4⁺ T‡	1279 ± 149	1994 ± 166	1097 ± 167	308 ± 38	<10

Data are mean ± SE, n = 12.

100 × 10⁶ CD4⁺ T cell–depleted spleen cells/recipient

5 × 10⁶ CD25^–CD4⁺ T cells/recipient

2.5 × 10⁶ CD25⁺CD4⁺ T cells/recipient