Univariate analysis for the risk of graft rejection
Variable . | No. patients . | No. events (%) . | Fisher exact test P . | Cumulative incidence of rejection, % (95% CI) . | P . |
|---|---|---|---|---|---|
| Sex | .46 | .43 | |||
| Female | 31 | 2 (6) | 8 (2-29) | ||
| Male | 41 | 5 (12) | 18 (6-35) | ||
| Sex mismatch in GvH direction, donor→recipient | NS | NS | |||
| Female→male | 19 | 2 (11) | 13 (3-47) | ||
| Other combinations | 53 | 5 (9) | 12 (5-27) | ||
| Sex mismatch in HvG direction, donor→recipient | NS | NS | |||
| Male→female | 18 | 1 (6) | 8 (1-51) | ||
| Other combinations | 54 | 6 (11) | 13 (3-47) | ||
| Patient age at HSCT | NS | NS | |||
| Younger than 15 y | 36 | 4 (11) | 14 (5-35) | ||
| 15 y or older | 36 | 3 (8) | 9 (3-26) | ||
| Donor age | .46 | .45 | |||
| Younger than 35 y | 31 | 2 (6) | 7 (2-25) | ||
| 35 y or older | 41 | 5 (12) | 15 (7-35) | ||
| Pesaro classification | NS* | NS | |||
| Class 1 | 21 | 3 (14) | 18 (6-51) | ||
| Class 2 | 20 | 1 (5) | 10 (3-37) | ||
| Class 3 | 31 | 2 (6) | 7 (2-25) | ||
| HCMV serology, donor→recipient | .50* | NS | |||
| Negative→negative | 7 | 1 (14) | 17 (3-100) | ||
| Negative→positive | 16 | 3 (19) | 24 (9-65) | ||
| Positive→negative | 14 | 1 (7) | 7 (1-47) | ||
| Positive→positive | 35 | 2 (6) | 6 (2-23) | ||
| HCMV serology combination, donor→recipient | NS | NS | |||
| Negative→negative | 7 | 1 (14) | 17 (3-100) | ||
| Others | 65 | 6 (9) | 11 (5-24) | ||
| Conditioning regimen | .14* | .14 | |||
| BU + CY | 18 | 3 (17) | 17 (6-48) | ||
| BU + TT + CY | 36 | 1 (3) | 3 (0-20) | ||
| BU + TT + FLU | 18 | 3 (17) | 23 (8-63) | ||
| Use of ATG | .36 | .32 | |||
| No | 54 | 4 (7) | 8 (3-19) | ||
| Yes | 18 | 3 (17) | 23 (8-63) | ||
| Cell dose infused, × 108/kg | NS | NS | |||
| Less than 5 | 44 | 4 (9) | 9 (4-24) | ||
| 5 or greater | 28 | 3 (11) | 14 (5-40) | ||
| HLA-DPB1 mismatch: | .08* | .048 | |||
| Matched + permissive | 45 | 2 (4) | 7 (2-26) | ||
| Nonpermissive mismatch in GvH direction | 10 | 1 (10) | 10 (2-64) | ||
| Nonpermissive mismatch in HvG direction | 17 | 4 (24) | 26 (11-60) |
Variable . | No. patients . | No. events (%) . | Fisher exact test P . | Cumulative incidence of rejection, % (95% CI) . | P . |
|---|---|---|---|---|---|
| Sex | .46 | .43 | |||
| Female | 31 | 2 (6) | 8 (2-29) | ||
| Male | 41 | 5 (12) | 18 (6-35) | ||
| Sex mismatch in GvH direction, donor→recipient | NS | NS | |||
| Female→male | 19 | 2 (11) | 13 (3-47) | ||
| Other combinations | 53 | 5 (9) | 12 (5-27) | ||
| Sex mismatch in HvG direction, donor→recipient | NS | NS | |||
| Male→female | 18 | 1 (6) | 8 (1-51) | ||
| Other combinations | 54 | 6 (11) | 13 (3-47) | ||
| Patient age at HSCT | NS | NS | |||
| Younger than 15 y | 36 | 4 (11) | 14 (5-35) | ||
| 15 y or older | 36 | 3 (8) | 9 (3-26) | ||
| Donor age | .46 | .45 | |||
| Younger than 35 y | 31 | 2 (6) | 7 (2-25) | ||
| 35 y or older | 41 | 5 (12) | 15 (7-35) | ||
| Pesaro classification | NS* | NS | |||
| Class 1 | 21 | 3 (14) | 18 (6-51) | ||
| Class 2 | 20 | 1 (5) | 10 (3-37) | ||
| Class 3 | 31 | 2 (6) | 7 (2-25) | ||
| HCMV serology, donor→recipient | .50* | NS | |||
| Negative→negative | 7 | 1 (14) | 17 (3-100) | ||
| Negative→positive | 16 | 3 (19) | 24 (9-65) | ||
| Positive→negative | 14 | 1 (7) | 7 (1-47) | ||
| Positive→positive | 35 | 2 (6) | 6 (2-23) | ||
| HCMV serology combination, donor→recipient | NS | NS | |||
| Negative→negative | 7 | 1 (14) | 17 (3-100) | ||
| Others | 65 | 6 (9) | 11 (5-24) | ||
| Conditioning regimen | .14* | .14 | |||
| BU + CY | 18 | 3 (17) | 17 (6-48) | ||
| BU + TT + CY | 36 | 1 (3) | 3 (0-20) | ||
| BU + TT + FLU | 18 | 3 (17) | 23 (8-63) | ||
| Use of ATG | .36 | .32 | |||
| No | 54 | 4 (7) | 8 (3-19) | ||
| Yes | 18 | 3 (17) | 23 (8-63) | ||
| Cell dose infused, × 108/kg | NS | NS | |||
| Less than 5 | 44 | 4 (9) | 9 (4-24) | ||
| 5 or greater | 28 | 3 (11) | 14 (5-40) | ||
| HLA-DPB1 mismatch: | .08* | .048 | |||
| Matched + permissive | 45 | 2 (4) | 7 (2-26) | ||
| Nonpermissive mismatch in GvH direction | 10 | 1 (10) | 10 (2-64) | ||
| Nonpermissive mismatch in HvG direction | 17 | 4 (24) | 26 (11-60) |
Chi-squared P