Table 2. HLA-DPB1 mismatches and... | American Society of Hematology

Table 2.

HLA-DPB1 mismatches and classification as permissive or nonpermissive in UD-recipient pairs from this study

		HLA-DPB1‡
Classification^* and UPN	Outcome†	Recipient	Donor
Permissive (n = 24)
1	—	0201	0201,0401
2	—	0201,0402	0201,0401
3	—	0401	0101,0401
4	—	0401,1101	0401,0402
5	—	0401	0401,0402
6	R	0201,0401	0401
7	R	0401	0201,0401
8	III	0301,1701	0401,1701
9	—	0201,0402	0402,1101
10	—	0201,0401	0401
11	—	0201,0402	0201,0401
12	—	0301,0402	0301,0401
13	II	0201,0301	0301,0401
14	—	0401	0401,0402
15	II	0201	0401
16	—	0402	0202,0401
17	—	0401	0201
18	—	0201	0401,0402
19	—	1401	0301
20	—	0101	0101,0401
21	—	0402,1601	0201,0401
22	—	0401,0402	0201,0401
23	II	0402	0402,1101
24	II	0301,0401	0201,0301
Nonpermissive HvG (n = 17)
25	II	0401,2401§	0301,0401
26	R	0201,0401	0201,0301
27	II	0401	00301,0401
28	II	0201,0401	0301,0401
29	—	0401,0402	0301,0402
30	—	0201,0401	0301,0401
31	—	0401,0402	0401,1001
32	II	0201	0301,0402
33	IV	0201	0301,0401
34	R	0401,0402	0201,0301
35	R	0201,1501	0401,1401
36	II, R	0401	0301,1301
37	—	0401,0601	1001,2301
38	—	0301,0401	1001
39	—	0201	0301,0401
40	II	0201,0401	0301,1701
41	IV	0201	0301,0401
Nonpermissive GvH (n = 10)
42	R	0401,1001	0301,0401
43	—	0201,0301	0201
44	III	0401,1001	0401,0501
45	—	0301,0401	0401,0402
46	—	1101,1701	0101,1101
47	—	0301,1701	0401,0402
48	III	1001	0301,1601
49	III	0301,0402	0401
50	—	0301,0401	0401
51	II	0401,1001	0402,2001

		HLA-DPB1‡
Classification^* and UPN	Outcome†	Recipient	Donor
Permissive (n = 24)
1	—	0201	0201,0401
2	—	0201,0402	0201,0401
3	—	0401	0101,0401
4	—	0401,1101	0401,0402
5	—	0401	0401,0402
6	R	0201,0401	0401
7	R	0401	0201,0401
8	III	0301,1701	0401,1701
9	—	0201,0402	0402,1101
10	—	0201,0401	0401
11	—	0201,0402	0201,0401
12	—	0301,0402	0301,0401
13	II	0201,0301	0301,0401
14	—	0401	0401,0402
15	II	0201	0401
16	—	0402	0202,0401
17	—	0401	0201
18	—	0201	0401,0402
19	—	1401	0301
20	—	0101	0101,0401
21	—	0402,1601	0201,0401
22	—	0401,0402	0201,0401
23	II	0402	0402,1101
24	II	0301,0401	0201,0301
Nonpermissive HvG (n = 17)
25	II	0401,2401§	0301,0401
26	R	0201,0401	0201,0301
27	II	0401	00301,0401
28	II	0201,0401	0301,0401
29	—	0401,0402	0301,0402
30	—	0201,0401	0301,0401
31	—	0401,0402	0401,1001
32	II	0201	0301,0402
33	IV	0201	0301,0401
34	R	0401,0402	0201,0301
35	R	0201,1501	0401,1401
36	II, R	0401	0301,1301
37	—	0401,0601	1001,2301
38	—	0301,0401	1001
39	—	0201	0301,0401
40	II	0201,0401	0301,1701
41	IV	0201	0301,0401
Nonpermissive GvH (n = 10)
42	R	0401,1001	0301,0401
43	—	0201,0301	0201
44	III	0401,1001	0401,0501
45	—	0301,0401	0401,0402
46	—	1101,1701	0101,1101
47	—	0301,1701	0401,0402
48	III	1001	0301,1601
49	III	0301,0402	0401
50	—	0301,0401	0401
51	II	0401,1001	0402,2001

UPN indicates unique patient number; —, neither GVHD nor rejection.

Classification of HLA-DPB1 mismatches as permissive or nonpermissive in HvG or GvH direction, according to the algorithm we previously described¹³

†

Outcome of each patient receiving a transplant in terms of occurrence of graft rejection (R) or acute GvHD grade II (II), III (III), or IV (IV), defined according to the criteria stated in “Patients and methods”

‡

Complete typing of HLA-DPB1 alleles present in the recipient and in the donor. Immunogenicity groups of HLA-DPB1 alleles according to the algorithm we previously described¹³ are indicated as follows: group 1, highly immunogenic (underlining); group 2, intermediately immunogenic (italics); group 3, poorly immunogenic (normal typeface)

HLA-DPB1^*2401 was assigned to group 3 of nonimmunogenic alleles on the basis of amino acid sequence homology with DPB1^*4601, the prototype of group 3 alleles, and not as all other alleles, on the basis of functional studies using alloreactive T lymphocytes¹³

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