Toxicity profile
Toxicity* . | N (%) . |
|---|---|
| Hepatotoxicity | |
| Grade 1 | 9 (12.5) |
| Grade 2 | 7 (9.7) |
| Grade 3 | 3 (4.1) |
| Grade 4 | 2 (2.7) |
| Neurotoxicity | |
| Grade 1 | 11 (15.2) |
| Grade 2 | 1 (1.3) |
| Grade 3 | 2 (2.7) |
| GIT: nausea, decreased appetite, dyspepsia; grade 1 | 7 (9.7) |
| Skin: hyperpigmentation, hypopigmentation, dryness; grade 1 | 18 (25) |
| Cardiac | |
| Nonspecific T-wave inversion, grade 1 | 1 (1.3) |
| SVT, grade 2 | 1 (1.3) |
| Weight gain | 4 (5.5) |
| Grade 1 | 1 (1.3) |
| Grade 3 | |
| Somnolence, grade 1 | 2 (2.7) |
| Definite differentiation syndrome | 5 (6.9) |
Toxicity* . | N (%) . |
|---|---|
| Hepatotoxicity | |
| Grade 1 | 9 (12.5) |
| Grade 2 | 7 (9.7) |
| Grade 3 | 3 (4.1) |
| Grade 4 | 2 (2.7) |
| Neurotoxicity | |
| Grade 1 | 11 (15.2) |
| Grade 2 | 1 (1.3) |
| Grade 3 | 2 (2.7) |
| GIT: nausea, decreased appetite, dyspepsia; grade 1 | 7 (9.7) |
| Skin: hyperpigmentation, hypopigmentation, dryness; grade 1 | 18 (25) |
| Cardiac | |
| Nonspecific T-wave inversion, grade 1 | 1 (1.3) |
| SVT, grade 2 | 1 (1.3) |
| Weight gain | 4 (5.5) |
| Grade 1 | 1 (1.3) |
| Grade 3 | |
| Somnolence, grade 1 | 2 (2.7) |
| Definite differentiation syndrome | 5 (6.9) |
Grades given are maximum grade according to NCI-CTC v2.0.