Table 5 Demographics and platelet... | American Society of Hematology

Table 5

Demographics and platelet counts, A-IPF, and bone marrow histology at a point in time in patients without a platelet response to treatment with TPO-A for a given duration

	Age, y	Sex	Splenectomy, yes/no	Duration of TPO-A treatment, mo	Platelet count, × 10⁹/L	A-IPF, × 10⁹/L	Megakaryocyte quantity	Megakaryocyte clustering	Reticulin fibrosis grade
	63	Female	Yes	6	12*	1.44*	1+	+	0
	35	Male	Yes	13	3*	1.79*	2+	+	1+
	55	Female	Yes	3	17*	5.61*	2+	+	1+
	5	Male	No	10	2*	0.71*	1+	+	0
	34	Female	No	9	11*	3.23*	1+	+	2+
	7	Male	Yes	2	2*	0.61*	3+	+	1+
	75	Male	No	8	2*	0.77*	2+	+	1+
	5	Male	No	9	12	3.00
	52	Male	Yes	3	19	2.85
	7	Female	No	3	34	4.76
	12	Female	No	6	11	3.78
Mean (SD)	32			6.55 (± 3.56)	11.36 (± 9.68)	2.60 (± 1.69)

	Age, y	Sex	Splenectomy, yes/no	Duration of TPO-A treatment, mo	Platelet count, × 10⁹/L	A-IPF, × 10⁹/L	Megakaryocyte quantity	Megakaryocyte clustering	Reticulin fibrosis grade
	63	Female	Yes	6	12*	1.44*	1+	+	0
	35	Male	Yes	13	3*	1.79*	2+	+	1+
	55	Female	Yes	3	17*	5.61*	2+	+	1+
	5	Male	No	10	2*	0.71*	1+	+	0
	34	Female	No	9	11*	3.23*	1+	+	2+
	7	Male	Yes	2	2*	0.61*	3+	+	1+
	75	Male	No	8	2*	0.77*	2+	+	1+
	5	Male	No	9	12	3.00
	52	Male	Yes	3	19	2.85
	7	Female	No	3	34	4.76
	12	Female	No	6	11	3.78
Mean (SD)	32			6.55 (± 3.56)	11.36 (± 9.68)	2.60 (± 1.69)

1+ indicates mild increase; 2+, moderate increase; 3+, severe increase; and 0, no increase.

Platelet counts and A-IPF values were measured on the day of the bone marrow examination.

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