Summary of the time points when immunologic disorders and severe weight loss were first observed*
| Mouse no. . | VL† . | Activated CD8‡§ . | IFN-ㆶ . | Weight loss§‖ . |
|---|---|---|---|---|
| Mouse 11 | 4 | 4 (± 0) | 4 (± 0) | – |
| Mouse 12 | 4 | 4 (± 0) | 4 (± 0) | 6 (+2) |
| Mouse 13 | 3 | 4 (+1) | 4 (+1) | 6 (+3) |
| Mouse 14 | 4 | 4 (± 0) | 4 (± 0) | 9 (+5) |
| Mouse 15 | 3 | 3 (± 0) | 4 (+1) | 8 (+5) |
| Mouse 16 | 4 | 4 (± 0) | 4 (± 0) | – |
| Mouse 17 | 3 | 4 (+1) | 4 (+1) | 6 (+3) |
| Mouse 18 | 3 | 4 (+1) | 4 (+1) | 5 (+2) |
| Average ± SEM** | – | 0.38 ± 0.18 | 0.50 ± 0.19 | 3.33 ± 0.56 |
| Mouse no. . | VL† . | Activated CD8‡§ . | IFN-ㆶ . | Weight loss§‖ . |
|---|---|---|---|---|
| Mouse 11 | 4 | 4 (± 0) | 4 (± 0) | – |
| Mouse 12 | 4 | 4 (± 0) | 4 (± 0) | 6 (+2) |
| Mouse 13 | 3 | 4 (+1) | 4 (+1) | 6 (+3) |
| Mouse 14 | 4 | 4 (± 0) | 4 (± 0) | 9 (+5) |
| Mouse 15 | 3 | 3 (± 0) | 4 (+1) | 8 (+5) |
| Mouse 16 | 4 | 4 (± 0) | 4 (± 0) | – |
| Mouse 17 | 3 | 4 (+1) | 4 (+1) | 6 (+3) |
| Mouse 18 | 3 | 4 (+1) | 4 (+1) | 5 (+2) |
| Average ± SEM** | – | 0.38 ± 0.18 | 0.50 ± 0.19 | 3.33 ± 0.56 |
VL indicates viral load; and wpi, weeks postinfection.
The time points when infected mice showed significant differences to mock-infected mice are presented as wpi.
The wpi when EBV DNA was firstly detected is presented.
The values in parentheses represent the difference of each parameters to VL.
The wpi when the parcentage CD8+CD45RO+CD38+HLA-DR+ cells in PBMCs of each infected mouse was more than the average of that of mock-infected mice + SD is presented.
The wpi when the concentration of IFN-γ in plasma of each infected mouse was more than the average of mock-infected mice + SD is presented.
The wpi when the value was more than the average of mock-infected mice − SD is presented.
The differences to VL (represented in parentheses) are summarized and presented as average ± SEM.