Summary of the time points when hematologic disorders and severe weight loss were first observed*
| Mouse no.† . | VL‡ . | Leukocytosis§¶ . | Erythropenia§‖ . | Thrombocytopenia§‖ . | HGB decrease§‖ . | Weight loss§‖ . |
|---|---|---|---|---|---|---|
| Mouse 1 | 5 | 7 (+2) | 6 (+1) | 6 (+1) | 6 (+1) | 9 (+4) |
| Mouse 2 | 5 | 8 (+3) | 9 (+4) | 8 (+3) | 9 (+4) | 9 (+4) |
| Mouse 3 | 3 | 8 (+5) | – | 9 (+6) | – | 10 (+7) |
| Mouse 4 | 4 | 5 (+1) | 6 (+2) | – | 6 (+2) | – |
| Mouse 5 | 5 | 6 (+1) | 6 (+1) | 8 (+3) | 8 (+3) | 8 (+3) |
| Mouse 6 | 3 | 3 (± 0) | 3 (± 0) | 3 (± 0) | 4 (+1) | 4 (+1) |
| Mouse 7 | 3 | 5 (+2) | 6 (+3) | 6 (+3) | 6 (+3) | 6 (+3) |
| Mouse 8 | 4 | 5 (+1) | – | 5 (+1) | – | 5 (+1) |
| Mouse 9 | 6 | 6 (± 0) | 7 (+1) | 6 (± 0) | 7 (+1) | 7 (+1) |
| Mouse 10 | 7 | 8 (+1) | 10 (+3) | – | – | 9 (+2) |
| Average ± SEM** | – | 1.60 ± 0.48 | 1.88 ± 0.48 | 2.13 ± 0.72 | 2.14 ± 0.46 | 2.89 ± 0.65 |
| Mouse no.† . | VL‡ . | Leukocytosis§¶ . | Erythropenia§‖ . | Thrombocytopenia§‖ . | HGB decrease§‖ . | Weight loss§‖ . |
|---|---|---|---|---|---|---|
| Mouse 1 | 5 | 7 (+2) | 6 (+1) | 6 (+1) | 6 (+1) | 9 (+4) |
| Mouse 2 | 5 | 8 (+3) | 9 (+4) | 8 (+3) | 9 (+4) | 9 (+4) |
| Mouse 3 | 3 | 8 (+5) | – | 9 (+6) | – | 10 (+7) |
| Mouse 4 | 4 | 5 (+1) | 6 (+2) | – | 6 (+2) | – |
| Mouse 5 | 5 | 6 (+1) | 6 (+1) | 8 (+3) | 8 (+3) | 8 (+3) |
| Mouse 6 | 3 | 3 (± 0) | 3 (± 0) | 3 (± 0) | 4 (+1) | 4 (+1) |
| Mouse 7 | 3 | 5 (+2) | 6 (+3) | 6 (+3) | 6 (+3) | 6 (+3) |
| Mouse 8 | 4 | 5 (+1) | – | 5 (+1) | – | 5 (+1) |
| Mouse 9 | 6 | 6 (± 0) | 7 (+1) | 6 (± 0) | 7 (+1) | 7 (+1) |
| Mouse 10 | 7 | 8 (+1) | 10 (+3) | – | – | 9 (+2) |
| Average ± SEM** | – | 1.60 ± 0.48 | 1.88 ± 0.48 | 2.13 ± 0.72 | 2.14 ± 0.46 | 2.89 ± 0.65 |
HGB indicates hemoglobin; VL, viral load; and wpi, weeks postinfection.
The time points when infected mice showed significant differences to mock-infected mice are presented as wpi.
The results from mice no. 2, 7, and 9 are shown in Figure 3.
The wpi when EBV DNA was firstly detected is presented.
The values in parentheses represent the difference of each parameters to VL.
The wpi when the value was more than the average of mock-infected mice + SD is presented.
The wpi when the value was more than the average of mock-infected mice − SD is presented.
The differences to VL (represented in parentheses) are summarized and presented as average ± SEM.