Table 1 Bortezomib sensitizers... | American Society of Hematology

Table 1

Bortezomib sensitizers identified in KMS11

Gene ID	No. of siRNA	GEP	Gene ID	No. of siRNA	GEP
BAZ1B	2	P	PSMB7	3	P
CCNK	2	ND	RAB 8B	3	P
CDC42SE2	3	P	RB1CC1	2	P
CDK5	2	P	STK6	2	P
CEBPA	2	P	TFAP4	2	P
CHD4	2	P	TFE3	2	P
CRKL	3	P	TNFAIP3	4	P
CTNNB1	2	P	TNK1	2	P
DCAMKL1	2	ND	TOP1	2	P
ENC1	2	P	USP8	2	P
MAST2	2	P	VAMP2	3	P
MDM4	2	P	VBP1	2	P
MIF	2	P	VDAC3	2	P
NCOR1	2	P	WTAP	3	P
NME7	2	P	XPC	2	P
OGT	2	P	XRCC5	2	P
PSMA5	3	P	YY1	3	P
PSMB2	4	P	ZNF197	2	P
PSMB3	4	P

Gene ID	No. of siRNA	GEP	Gene ID	No. of siRNA	GEP
BAZ1B	2	P	PSMB7	3	P
CCNK	2	ND	RAB 8B	3	P
CDC42SE2	3	P	RB1CC1	2	P
CDK5	2	P	STK6	2	P
CEBPA	2	P	TFAP4	2	P
CHD4	2	P	TFE3	2	P
CRKL	3	P	TNFAIP3	4	P
CTNNB1	2	P	TNK1	2	P
DCAMKL1	2	ND	TOP1	2	P
ENC1	2	P	USP8	2	P
MAST2	2	P	VAMP2	3	P
MDM4	2	P	VBP1	2	P
MIF	2	P	VDAC3	2	P
NCOR1	2	P	WTAP	3	P
NME7	2	P	XPC	2	P
OGT	2	P	XRCC5	2	P
PSMA5	3	P	YY1	3	P
PSMB2	4	P	ZNF197	2	P
PSMB3	4	P

Bortezomib sensitizers were defined as genes targeted by at least 2 distinct siRNAs that decrease EC₅₀ by 2 SDs from the EC₅₀ of cells treated with control siRNAs. After excluding the genes that have absent call in KMS11 GEP, 37 targets were selected. Gene symbol (Gene ID), number of sensitizing siRNA, and expression status in GEP are presented for each hit.

GEP indicates gene expression profile; and P, present call.

View Large

This Feature Is Available To Subscribers Only