Table 1

SNPs rs10484561 and rs6457327 association with risk of developing FL in the United Kingdom

SNP/genotypeGenotype count
MAF (cases/control)HWE controlsVariant allele OR (95% CI)‡Allelic OR (95% CI)‡Allelic PTrend PGenotypic P
Cases*Controls†
rs10484561   0.21/0.11 0.924 2.40 (1.80-3.19) 2.07 (1.61-2.63) 3.502 × 10-9 2.743 × 10-9 6.342 × 10-9 
    GG 5 34        
    GT 82 548        
    TT 131 2102        
rs6457327   0.32/0.39 0.808 0.77 (0.58-1.01) 0.75 (0.61-0.93) .008 .008 .0190 
    AA 19 408        
    AC 103 1272        
    CC 96 1011        
SNP/genotypeGenotype count
MAF (cases/control)HWE controlsVariant allele OR (95% CI)‡Allelic OR (95% CI)‡Allelic PTrend PGenotypic P
Cases*Controls†
rs10484561   0.21/0.11 0.924 2.40 (1.80-3.19) 2.07 (1.61-2.63) 3.502 × 10-9 2.743 × 10-9 6.342 × 10-9 
    GG 5 34        
    GT 82 548        
    TT 131 2102        
rs6457327   0.32/0.39 0.808 0.77 (0.58-1.01) 0.75 (0.61-0.93) .008 .008 .0190 
    AA 19 408        
    AC 103 1272        
    CC 96 1011        

MAF indicates minor allele frequency; HWE, Hardy-Weinberg equilibrium; and CI, confidence interval.

*

FL cases from St Bartholomew's Hospital (n = 218 for both SNPs). In a validation series (10% of FL cases), direct sequencing results for each SNP genotype were fully concordant with the AD-PCR genotype results.

†

Controls from WTCCC2 1958 birth cohort (after filtering for missing genotype, population outliers, and relatedness: n = 2684 for rs10484561; n = 2691 for rs6457327). Both control populations maintain HWE.

‡

ORs calculated for the variant allele carriers (homozygous or heterozygous) vs homozygous common allele carriers (Variant allele OR) and for the minor vs the major allele (Allelic OR).

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