Table 3

Th17 and Treg numbers in 30 patients with and without pathologic digestive GVHD, according to conditioning regimen (second cohort)

Acute GVHD MAC (n = 11)Acute GVHD RIC (n = 10)No GVHD (n = 9)
Th17,* median (range) 0 (0-1) 0 (0-2) 3 (2-7) 
Treg,* median (range) 3 (1-7) 3.5 (2-6) 0 (0-1) 
Th17/Treg,* median (range) 0.25 (0.14-0.50) 0.21 (0.10-0.50) 4.00 (3.00-10.00) 
Th17/Treg < 1, n (%) 11 (100) 10 (100) 0 (0) 
Acute GVHD MAC (n = 11)Acute GVHD RIC (n = 10)No GVHD (n = 9)
Th17,* median (range) 0 (0-1) 0 (0-2) 3 (2-7) 
Treg,* median (range) 3 (1-7) 3.5 (2-6) 0 (0-1) 
Th17/Treg,* median (range) 0.25 (0.14-0.50) 0.21 (0.10-0.50) 4.00 (3.00-10.00) 
Th17/Treg < 1, n (%) 11 (100) 10 (100) 0 (0) 

MAC indicates myeloablative conditioning regimen; and RIC, reduced-intensity conditioning.

*

P < .001 for GVHD versus no GVHD after MAC and for GVHD versus no GVHD after RIC (by Mann-Whitney test).

P < .001 by Fisher exact test.

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