Correlations of Th17 and Treg numbers, and Th17/Treg ratio with other GVHD pathologic markers (first cohort)
| . | Th17 > 4 . | Treg > 4 . | Th17/Treg < 1 . | P* . |
|---|---|---|---|---|
| Apoptotic epithelial cells (TUNEL) | ||||
| No (n = 6) | 5 | 0 | 0 | .001 |
| Yes (n = 34) | 3 | 19 | 25 | |
| More than 5 per field (n = 29) | 0 | 10 | 15 | .03 |
| Less than 5 per field (n = 11) | 8 | 9 | 10 | |
| Apoptotic cells within the infiltrate (TUNEL) | ||||
| No (n = 19) | 8 | 3 | 7 | .03 |
| Yes (n = 21) | 0 | 16 | 18 | |
| Fas expression within the cellular infiltrate | ||||
| No (n = 17) | 7 | 1 | 6 | .003 |
| Yes (n = 23) | 1 | 18 | 19 | |
| More than 5 cells per field (n = 8) | 0 | 7 | 1 | .2 |
| Less than 5 cells per field (n = 32) | 8 | 12 | 18 | |
| TNF receptor 1 | ||||
| No (n = 14) | 8 | 0 | 3 | < .001 |
| Yes (n = 26) | 0 | 19 | 22 | |
| TNF receptor 2 | ||||
| No (15) | 8 | 0 | 3 | < .001 |
| Yes (n = 25) | 0 | 19 | 22 | |
| TNF | ||||
| Less than 20 cells per field (n = 20) | 8 | 2 | 7 | < .001 |
| More than 20 cells per field (n = 20) | 0 | 17 | 18 |
| . | Th17 > 4 . | Treg > 4 . | Th17/Treg < 1 . | P* . |
|---|---|---|---|---|
| Apoptotic epithelial cells (TUNEL) | ||||
| No (n = 6) | 5 | 0 | 0 | .001 |
| Yes (n = 34) | 3 | 19 | 25 | |
| More than 5 per field (n = 29) | 0 | 10 | 15 | .03 |
| Less than 5 per field (n = 11) | 8 | 9 | 10 | |
| Apoptotic cells within the infiltrate (TUNEL) | ||||
| No (n = 19) | 8 | 3 | 7 | .03 |
| Yes (n = 21) | 0 | 16 | 18 | |
| Fas expression within the cellular infiltrate | ||||
| No (n = 17) | 7 | 1 | 6 | .003 |
| Yes (n = 23) | 1 | 18 | 19 | |
| More than 5 cells per field (n = 8) | 0 | 7 | 1 | .2 |
| Less than 5 cells per field (n = 32) | 8 | 12 | 18 | |
| TNF receptor 1 | ||||
| No (n = 14) | 8 | 0 | 3 | < .001 |
| Yes (n = 26) | 0 | 19 | 22 | |
| TNF receptor 2 | ||||
| No (15) | 8 | 0 | 3 | < .001 |
| Yes (n = 25) | 0 | 19 | 22 | |
| TNF | ||||
| Less than 20 cells per field (n = 20) | 8 | 2 | 7 | < .001 |
| More than 20 cells per field (n = 20) | 0 | 17 | 18 |
Fisher exact test for the association of Th17/Treg < 1 with the other pathologic parameters.