Cox proportional hazards modeling of risk factors for ATL development
| . | Univariate analysis . | Multivariate analysis . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Male sex (vs female) | 0.74 (0.23-2.37) | .61 | 0.38 (0.12-1.18) | .09 |
| Square-root transformed VL per unit increase | 2.55 (1.91-3.41) | < .001 | 3.57 (2.25-5.68) | < .001 |
| Age per 5-year increase from 40 y | 1.20 (0.94-1.53) | .15 | 1.67 (1.12-2.50) | .012 |
| Family history of ATL (vs others) | 2.68 (0.80-8.98) | .11 | 12.1 (2.26-64.7) | .004 |
| First opportunity for HTLV-1 testing during treatment of other diseases (vs others) | 3.40 (1.12-10.28) | .03 | 4.16 (1.37-12.6) | .012 |
| . | Univariate analysis . | Multivariate analysis . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Male sex (vs female) | 0.74 (0.23-2.37) | .61 | 0.38 (0.12-1.18) | .09 |
| Square-root transformed VL per unit increase | 2.55 (1.91-3.41) | < .001 | 3.57 (2.25-5.68) | < .001 |
| Age per 5-year increase from 40 y | 1.20 (0.94-1.53) | .15 | 1.67 (1.12-2.50) | .012 |
| Family history of ATL (vs others) | 2.68 (0.80-8.98) | .11 | 12.1 (2.26-64.7) | .004 |
| First opportunity for HTLV-1 testing during treatment of other diseases (vs others) | 3.40 (1.12-10.28) | .03 | 4.16 (1.37-12.6) | .012 |
Analyses were performed using robust sandwich variance estimates.
ATL indicates adult T-cell leukemia; HTLV-1, human T-cell leukemia virus type 1; VL, HTLV-1 proviral load; HR, hazard ratio; and CI, confidence interval.