Best-fitting parameters for the neutrophil labeling data of 5 healthy volunteers
| Volunteer . | d (days−1) . | Half-life (days) . | Lifespan (days) . | Δ (days) . |
|---|---|---|---|---|
| A | 0.186 (0.156-0.241) | 3.73 | 5.38 | 5.80 (4.92-6.91) |
| B | 0.197 (0.160-0.250) | 3.52 | 5.08 | 6.01 (5.13-6.84) |
| C | 0.185 (0.145-0.218) | 3.75 | 5.41 | 6.14 (5.22-6.54) |
| D | 0.119 (0.077-0.192) | 5.83 | 8.40 | 3.94 (0.19-6.61) |
| E | 0.135 (0.106-0.211) | 5.13 | 7.41 | 2.33 (0.23-4.70) |
| Median | 0.185 | 3.75 | 5.41 | 5.80 |
| Volunteer . | d (days−1) . | Half-life (days) . | Lifespan (days) . | Δ (days) . |
|---|---|---|---|---|
| A | 0.186 (0.156-0.241) | 3.73 | 5.38 | 5.80 (4.92-6.91) |
| B | 0.197 (0.160-0.250) | 3.52 | 5.08 | 6.01 (5.13-6.84) |
| C | 0.185 (0.145-0.218) | 3.75 | 5.41 | 6.14 (5.22-6.54) |
| D | 0.119 (0.077-0.192) | 5.83 | 8.40 | 3.94 (0.19-6.61) |
| E | 0.135 (0.106-0.211) | 5.13 | 7.41 | 2.33 (0.23-4.70) |
| Median | 0.185 | 3.75 | 5.41 | 5.80 |
d represents the average turnover rate of neutrophils (which represents their production and loss rate in steady state conditions). Δ represents the delay with which labeled cells from the BM reach the blood. Average lifespans were calculated as 1/d or were converted to half-lives as ln2/d. Values in parentheses are 95% confidence intervals as determined by bootstrapping.