Combination Index values of dexamethasone and vorinostat against glucocorticoid-resistant ALL xenografts in vitro
| . | ED50 . | ED75 . | ED90 . | ED95 . |
|---|---|---|---|---|
| ALL-2 | 0.22 | 0.26 | 0.31 | 0.35 |
| ALL-19 | 0.95 | 0.74 | 0.58 | 0.49 |
| . | ED50 . | ED75 . | ED90 . | ED95 . |
|---|---|---|---|---|
| ALL-2 | 0.22 | 0.26 | 0.31 | 0.35 |
| ALL-19 | 0.95 | 0.74 | 0.58 | 0.49 |
CI < 0.9, synergism; CI 0.9-1.1, additive effects; CI > 1.1, antagonism.
ALL indicates acute lymphoblastic leukemia; CI, confidence interval; and ED, effective dose for each compound to cause cytotoxicity to the indicated proportion of cells.