Table 3

Association of EBV serostatus and category of EBV antibody titer with risk of all NHL, stratified by time to diagnosis

ExposureFollow-up < 5 y
Follow-up ≥ 5 y
P for interaction
Cases, nControls, nRR* (95% CI)Cases, nControls, nRR* (95% CI)
EBV serostatus       .38 
    Positive 71 156 Ref 248 473 Ref  
    Negative 11 4.39 (1.37-14.09) 10 28 0.63 (0.30-1.34)  
Anti–EBNA-1, titer       .22 
    < 320 62 130 Ref 190 375 Ref  
    ≥ 320 26 0.76 (0.32-1.79) 58 98 1.16 (0.80-1.69)  
Anti–EBNA-2, titer       .33 
    < 80 60 129 Ref 196 383 Ref  
    ≥ 80 11 27 0.87 (0.38-2.00) 52 90 1.11 (0.76-1.64)  
Anti-VCA, titer       .94 
    < 10 240 58 135 Ref 217 418 Ref  
    ≥ 10 240 13 21 1.36 (0.62-2.99) 31 55 1.10 (0.68-1.78)  
Anti-EA, titer       .88 
    < 640 56 125 Ref 212 400 Ref  
    ≥ 640 15 31 1.02 (0.49-2.12) 36 73 0.91 (0.59-1.42)  
EBNA-1/EBNA-2 ratio       .62 
    > 1.0 37 98 Ref 173 326 Ref  
    ≥ 1.0 34 58 1.54 (0.85-2.79) 75 147 0.9 (0.68-1.34)  
ExposureFollow-up < 5 y
Follow-up ≥ 5 y
P for interaction
Cases, nControls, nRR* (95% CI)Cases, nControls, nRR* (95% CI)
EBV serostatus       .38 
    Positive 71 156 Ref 248 473 Ref  
    Negative 11 4.39 (1.37-14.09) 10 28 0.63 (0.30-1.34)  
Anti–EBNA-1, titer       .22 
    < 320 62 130 Ref 190 375 Ref  
    ≥ 320 26 0.76 (0.32-1.79) 58 98 1.16 (0.80-1.69)  
Anti–EBNA-2, titer       .33 
    < 80 60 129 Ref 196 383 Ref  
    ≥ 80 11 27 0.87 (0.38-2.00) 52 90 1.11 (0.76-1.64)  
Anti-VCA, titer       .94 
    < 10 240 58 135 Ref 217 418 Ref  
    ≥ 10 240 13 21 1.36 (0.62-2.99) 31 55 1.10 (0.68-1.78)  
Anti-EA, titer       .88 
    < 640 56 125 Ref 212 400 Ref  
    ≥ 640 15 31 1.02 (0.49-2.12) 36 73 0.91 (0.59-1.42)  
EBNA-1/EBNA-2 ratio       .62 
    > 1.0 37 98 Ref 173 326 Ref  
    ≥ 1.0 34 58 1.54 (0.85-2.79) 75 147 0.9 (0.68-1.34)  

EBV indicates Epstein-Barr virus; NHL, non-Hodgkin lymphoma; EBNA, Epstein-Barr nuclear antigen; VCA, viral capsid antigen; EA, early antigen; RR: rate ratio; and CI, confidence interval.

*

Unconditional logistic regression adjusting for the matching factors (sex/study, age, race, month and year of blood draw, fasting status).

Among EBV-seropositive subjects only.

or Create an Account

Close Modal
Close Modal