Univariate and multivariate Cox proportional hazard models for overall survival in cardiac amyloidosis
| . | Univariate . | Multivariate model 1 . | Multivariate model 2 . | Multivariate model 3 . | ||||
|---|---|---|---|---|---|---|---|---|
| χ2 . | P . | χ2 . | P . | χ2 . | P . | χ2 . | P . | |
| Male sex | 0.502 | .479 | 0.284 | .594 | 0.800 | .371 | 0.370 | .543 |
| Age, y | 4.103 | .043 | 1.982 | .159 | 0.399 | .528 | 1.453 | .228 |
| No. of organs involved | 0.256 | .613 | 0.010 | .919 | 0.005 | .945 | 0.036 | .849 |
| Lambda type of light chain | 1.061 | .303 | 2.171 | .141 | 1.673 | .196 | 2.110 | .146 |
| LV ejection fraction (< 45%) | 18.541 | < .001 | 5.725 | .017 | 0.001 | .992 | 3.010 | .083 |
| NYHA (< 3) | 50.617 | < .001 | 2.267 | .132 | 0.711 | .399 | 2.531 | .112 |
| EGFR | 5.696 | .017 | 3.644 | .054 | 1.210 | .271 | 3.989 | .046 |
| hs-TnT plasma level | 21.402 | < .001 | 6.349 | .012 | 3.930 | .047 | — | — |
| Troponin T (fourth generation) | — | — | — | — | — | — | 6.442 | .011 |
| NT-proBNP plasma level | 17.814 | < .001 | 19.397 | < .001 | 11.487 | < .001 | 15.883 | < .001 |
| Myocardial mass | 7.065 | .008 | 1.800 | .180 | 0.04 | .950 | 3.952 | .047 |
| . | Univariate . | Multivariate model 1 . | Multivariate model 2 . | Multivariate model 3 . | ||||
|---|---|---|---|---|---|---|---|---|
| χ2 . | P . | χ2 . | P . | χ2 . | P . | χ2 . | P . | |
| Male sex | 0.502 | .479 | 0.284 | .594 | 0.800 | .371 | 0.370 | .543 |
| Age, y | 4.103 | .043 | 1.982 | .159 | 0.399 | .528 | 1.453 | .228 |
| No. of organs involved | 0.256 | .613 | 0.010 | .919 | 0.005 | .945 | 0.036 | .849 |
| Lambda type of light chain | 1.061 | .303 | 2.171 | .141 | 1.673 | .196 | 2.110 | .146 |
| LV ejection fraction (< 45%) | 18.541 | < .001 | 5.725 | .017 | 0.001 | .992 | 3.010 | .083 |
| NYHA (< 3) | 50.617 | < .001 | 2.267 | .132 | 0.711 | .399 | 2.531 | .112 |
| EGFR | 5.696 | .017 | 3.644 | .054 | 1.210 | .271 | 3.989 | .046 |
| hs-TnT plasma level | 21.402 | < .001 | 6.349 | .012 | 3.930 | .047 | — | — |
| Troponin T (fourth generation) | — | — | — | — | — | — | 6.442 | .011 |
| NT-proBNP plasma level | 17.814 | < .001 | 19.397 | < .001 | 11.487 | < .001 | 15.883 | < .001 |
| Myocardial mass | 7.065 | .008 | 1.800 | .180 | 0.04 | .950 | 3.952 | .047 |
Multivariate analysis model 1 indicates all patients, hs-TnT; Multivariate analysis model 2, EGFR > 30 mL/min × 1.73, hs-TnT; Multivariate analysis model 3, all patients, fourth-generation assay TnT; —, not applicable; NYHA, New York Heart Association; and EGFR, estimated glomerular filtration rate.