Hematologic analyses of diseased IRF-4/8 DKO and IRF-4+/−/IRF-8−/− mice
| Characteristic/location . | IRF-4/8 DKO (n = 4) . | IRF-4+/−/IRF-8−/− (n = 4) . |
|---|---|---|
| Gr1+Mac1+ (%) | ||
| ML | 2.15 ± 0.73 | 51.1 ± 19.6 |
| PB | 82 ± 7.10 | 78.1 ± 6.53 |
| BM | 95.5 ± 0.97 | 95.6 ± 1.68 |
| SP | 56.7 ± 19.73 | 23.4 ± 9.00 |
| PE | 32.6 ± 17.35 | 40.7 ± 24.83 |
| B220+ (%) | ||
| ML | 69.6 ± 15.06 | 15.9 ± 6.59 |
| PE | 36.45 ± 15.43 | 12.67 ± 4.52 |
| Tissue weight (g) | ||
| SP | 0.38 ± 0.05 | 0.41 ± 0.11 |
| LV | 1.24 ± 0.19 | 0.74 ± 0.15 |
| ML | 0.81 ± 0.14 | 0.08 ± 0.01 |
| Pleural effusion (mL) | 0.49 ± 0.32 | 0.70 ± 0.43 |
| Total BM cells from hind limbs (×107 cells) | 18 ± 3.57 | 9.41 ± 1.99 |
| Characteristic/location . | IRF-4/8 DKO (n = 4) . | IRF-4+/−/IRF-8−/− (n = 4) . |
|---|---|---|
| Gr1+Mac1+ (%) | ||
| ML | 2.15 ± 0.73 | 51.1 ± 19.6 |
| PB | 82 ± 7.10 | 78.1 ± 6.53 |
| BM | 95.5 ± 0.97 | 95.6 ± 1.68 |
| SP | 56.7 ± 19.73 | 23.4 ± 9.00 |
| PE | 32.6 ± 17.35 | 40.7 ± 24.83 |
| B220+ (%) | ||
| ML | 69.6 ± 15.06 | 15.9 ± 6.59 |
| PE | 36.45 ± 15.43 | 12.67 ± 4.52 |
| Tissue weight (g) | ||
| SP | 0.38 ± 0.05 | 0.41 ± 0.11 |
| LV | 1.24 ± 0.19 | 0.74 ± 0.15 |
| ML | 0.81 ± 0.14 | 0.08 ± 0.01 |
| Pleural effusion (mL) | 0.49 ± 0.32 | 0.70 ± 0.43 |
| Total BM cells from hind limbs (×107 cells) | 18 ± 3.57 | 9.41 ± 1.99 |
ML indicates mediastinal lymphoma; PB, peripheral blood; BM, bone marrow; SP, spleen; PE, pleural effusion; and LV, liver.