Table 6

Validation of translocations: PAM analysis generating classifiers to predict translocations t(11;14), t(4;14), and t(14;16)/t(14;20)

t(4;14)t(11;14)t(14;16)/t(14;20)
Samples in training set    
    Translocations 26 24 
    Total 153 143 143 
Samples in test set    
    Translocations 11 13 
    Total 80 75 73 
No. of probes in classifier 25 18 
PPV, % 84.6 83.3 80.0 
NPV, % 100.0 96.8 100.0 
Sn, % 100.0 83.3 100.0 
Sp, % 97.1 96.8 98.5 
Correctly classified, % 97.5 94.7 98.6 
t(4;14)t(11;14)t(14;16)/t(14;20)
Samples in training set    
    Translocations 26 24 
    Total 153 143 143 
Samples in test set    
    Translocations 11 13 
    Total 80 75 73 
No. of probes in classifier 25 18 
PPV, % 84.6 83.3 80.0 
NPV, % 100.0 96.8 100.0 
Sn, % 100.0 83.3 100.0 
Sp, % 97.1 96.8 98.5 
Correctly classified, % 97.5 94.7 98.6 

Per translocation, the number of samples harboring the specific translocation and total number of samples in the training set and test set, the number of probe sets in the classifier, and the PPV, NPV, Sn, and Sp are shown.

NPV indicates negative predictive value; PAM, prediction analysis of microarrays; PPV, positive predictive value; Sn, sensitivity; and Sp, specificity.