Validation of translocations: PAM analysis generating classifiers to predict translocations t(11;14), t(4;14), and t(14;16)/t(14;20)
. | t(4;14) . | t(11;14) . | t(14;16)/t(14;20) . |
---|---|---|---|
Samples in training set | |||
Translocations | 26 | 24 | 5 |
Total | 153 | 143 | 143 |
Samples in test set | |||
Translocations | 11 | 13 | 4 |
Total | 80 | 75 | 73 |
No. of probes in classifier | 25 | 5 | 18 |
PPV, % | 84.6 | 83.3 | 80.0 |
NPV, % | 100.0 | 96.8 | 100.0 |
Sn, % | 100.0 | 83.3 | 100.0 |
Sp, % | 97.1 | 96.8 | 98.5 |
Correctly classified, % | 97.5 | 94.7 | 98.6 |
. | t(4;14) . | t(11;14) . | t(14;16)/t(14;20) . |
---|---|---|---|
Samples in training set | |||
Translocations | 26 | 24 | 5 |
Total | 153 | 143 | 143 |
Samples in test set | |||
Translocations | 11 | 13 | 4 |
Total | 80 | 75 | 73 |
No. of probes in classifier | 25 | 5 | 18 |
PPV, % | 84.6 | 83.3 | 80.0 |
NPV, % | 100.0 | 96.8 | 100.0 |
Sn, % | 100.0 | 83.3 | 100.0 |
Sp, % | 97.1 | 96.8 | 98.5 |
Correctly classified, % | 97.5 | 94.7 | 98.6 |
Per translocation, the number of samples harboring the specific translocation and total number of samples in the training set and test set, the number of probe sets in the classifier, and the PPV, NPV, Sn, and Sp are shown.
NPV indicates negative predictive value; PAM, prediction analysis of microarrays; PPV, positive predictive value; Sn, sensitivity; and Sp, specificity.