Confusion matrices comparing with UAMS classification: HOVON 65 samples clustered with 50 up- and 50 down-regulated UAMS probe sets
| . | CD-1 . | CD-2 . | MS . | MF . | HY . | PR . | LB . | NFκB . | Class error rate . |
|---|---|---|---|---|---|---|---|---|---|
| CD-1 | 8 | 0 | 0 | 0 | 1 | 0 | 4 | 0 | 0.38 |
| CD-2 | 1 | 28 | 0 | 0 | 1 | 0 | 4 | 0 | 0.18 |
| MS | 0 | 0 | 31 | 0 | 0 | 1 | 0 | 1 | 0.06 |
| MF | 0 | 0 | 0 | 17 | 0 | 0 | 0 | 0 | 0.00 |
| HY | 1 | 0 | 0 | 2 | 63 | 4 | 6 | 1 | 0.18 |
| PR | 2 | 0 | 0 | 2 | 2 | 9 | 0 | 0 | 0.40 |
| LB | 0 | 0 | 0 | 2 | 0 | 0 | 13 | 0 | 0.13 |
| NFκB | 0 | 8 | 0 | 1 | 1 | 1 | 0 | 26 | 0.30 |
| CTA | 0 | 5 | 0 | 0 | 5 | 8 | 0 | 4 | NA |
| PRL3 | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 2 | NA |
| Myeloid | 4 | 0 | 7 | 12 | 4 | 5 | 1 | 6 | NA |
| NA | 3 | 0 | 0 | 0 | 1 | 0 | 5 | 0 | NA |
| . | CD-1 . | CD-2 . | MS . | MF . | HY . | PR . | LB . | NFκB . | Class error rate . |
|---|---|---|---|---|---|---|---|---|---|
| CD-1 | 8 | 0 | 0 | 0 | 1 | 0 | 4 | 0 | 0.38 |
| CD-2 | 1 | 28 | 0 | 0 | 1 | 0 | 4 | 0 | 0.18 |
| MS | 0 | 0 | 31 | 0 | 0 | 1 | 0 | 1 | 0.06 |
| MF | 0 | 0 | 0 | 17 | 0 | 0 | 0 | 0 | 0.00 |
| HY | 1 | 0 | 0 | 2 | 63 | 4 | 6 | 1 | 0.18 |
| PR | 2 | 0 | 0 | 2 | 2 | 9 | 0 | 0 | 0.40 |
| LB | 0 | 0 | 0 | 2 | 0 | 0 | 13 | 0 | 0.13 |
| NFκB | 0 | 8 | 0 | 1 | 1 | 1 | 0 | 26 | 0.30 |
| CTA | 0 | 5 | 0 | 0 | 5 | 8 | 0 | 4 | NA |
| PRL3 | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 2 | NA |
| Myeloid | 4 | 0 | 7 | 12 | 4 | 5 | 1 | 6 | NA |
| NA | 3 | 0 | 0 | 0 | 1 | 0 | 5 | 0 | NA |
Comparing HOVON-65/GMMG-HD4 and UAMS classification: The top 50 up- and top 50 down-regulated genes of all 7 UAMS clusters were used to cluster the HOVON-65/GMMG-HD4 samples. NFκB is marked because the gene signature was very weak, on the basis of the expression of BCL10 and high NFκB index.
CTA indicates cancer testis antigens; HOVON, Dutch-Belgian Cooperative Trial Group for Hemato-Oncology; HY, hyperdiploid cluster; LB, low percentage of bone disease; NA, class error rate not determined because there were no corresponding subgroups; NFκB, nuclear factor kappa light-chain-enhancer of activated B cells; PR, proliferation-associated genes; and UAMS, University of Arkansas for Medical Sciences.