Confusion matrices comparing with TC classification: H65 samples assigned to TC classes on the basis of TC criteria
| . | 11q13 . | D1 . | D2 . | D1 + D2 . | 6p21 . | maf . | 4p16 . | None . | Class error rate . |
|---|---|---|---|---|---|---|---|---|---|
| CD-1 | 4 | 6 | 1 | 2 | 0 | 0 | 0 | 0 | 0.69 |
| CD-2 | 25 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0.26 |
| MS | 0 | 0 | 0 | 0 | 0 | 0 | 33 | 0 | 0.00 |
| MF | 0 | 0 | 5 | 0 | 0 | 12 | 0 | 0 | 0.29 |
| HY | 1 | 66 | 0 | 6 | 0 | 2 | 0 | 2 | NA |
| PR | 0 | 8 | 5 | 0 | 1 | 0 | 0 | 1 | NA |
| LB | 0 | 3 | 9 | 1 | 0 | 1 | 0 | 1 | NA |
| NFκB | 1 | 23 | 6 | 1 | 0 | 1 | 1 | 4 | NA |
| CTA | 1 | 8 | 8 | 2 | 1 | 0 | 0 | 2 | NA |
| PRL3 | 0 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | NA |
| Myeloid | 1 | 13 | 13 | 5 | 0 | 0 | 6 | 1 | NA |
| NA | 0 | 5 | 3 | 0 | 1 | 0 | 0 | 0 | NA |
| . | 11q13 . | D1 . | D2 . | D1 + D2 . | 6p21 . | maf . | 4p16 . | None . | Class error rate . |
|---|---|---|---|---|---|---|---|---|---|
| CD-1 | 4 | 6 | 1 | 2 | 0 | 0 | 0 | 0 | 0.69 |
| CD-2 | 25 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0.26 |
| MS | 0 | 0 | 0 | 0 | 0 | 0 | 33 | 0 | 0.00 |
| MF | 0 | 0 | 5 | 0 | 0 | 12 | 0 | 0 | 0.29 |
| HY | 1 | 66 | 0 | 6 | 0 | 2 | 0 | 2 | NA |
| PR | 0 | 8 | 5 | 0 | 1 | 0 | 0 | 1 | NA |
| LB | 0 | 3 | 9 | 1 | 0 | 1 | 0 | 1 | NA |
| NFκB | 1 | 23 | 6 | 1 | 0 | 1 | 1 | 4 | NA |
| CTA | 1 | 8 | 8 | 2 | 1 | 0 | 0 | 2 | NA |
| PRL3 | 0 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | NA |
| Myeloid | 1 | 13 | 13 | 5 | 0 | 0 | 6 | 1 | NA |
| NA | 0 | 5 | 3 | 0 | 1 | 0 | 0 | 0 | NA |
Comparing HOVON-65/GMMG-HD4 and TC classification: HOVON-65/GMMG-HD4 samples are assigned to TC classes on the basis of expression of CCND1, MMSET, FGFR3, ITGB7, c-MAF, and CCND3 expression according to TC criteria. In lieu of normal bone marrow samples, for assignment of samples to D1, D1 + D2, and D2 classes, the threshold expression value of 30, as explained in “Methods,” was used as a reference value for normal bone marrow. Class error rate is depicted in the last column.
CTA indicates cancer testis antigens; HOVON, Dutch-Belgian Cooperative Trial Group for Hemato-Oncology; HY, hyperdiploid cluster; LB, low percentage of bone disease; NA, class error rate not determined because there were no corresponding subgroups; NFκB, nuclear factor kappa light-chain-enhancer of activated B cells; PR, proliferation-associated genes; and TC, translocation and cyclin D.