Multivariate analysis of pEFS at 5 years for LOH6q status, NOTCH1 status and FBXW7 status and general condition at diagnosis
| Parameters . | HR . | LL . | UL . | p(χ) . |
|---|---|---|---|---|
| General condition at diagnosis | 0.93 | 0.27 | 3.23 | 0.907 |
| LOH6q | 2.79 | 1.08 | 7.21 | 0.035 |
| NOTCH1 mutation | 0.36 | 0.14 | 0.91 | 0.031 |
| FBXW7 mutation | 1.13 | 0.31 | 4.09 | 0.854 |
| Parameters . | HR . | LL . | UL . | p(χ) . |
|---|---|---|---|---|
| General condition at diagnosis | 0.93 | 0.27 | 3.23 | 0.907 |
| LOH6q | 2.79 | 1.08 | 7.21 | 0.035 |
| NOTCH1 mutation | 0.36 | 0.14 | 0.91 | 0.031 |
| FBXW7 mutation | 1.13 | 0.31 | 4.09 | 0.854 |
HR, hazard ratio; LL, lower limit; UL, upper limit.
A Cox proportional hazards model was used to obtain the estimates and the 95% confidence interval of the relative risk for prognostic factors. In multivariate analysis considering general condition at diagnosis, which is itself a statistically significant poor-prognosis parameter in pediatric T-LBL (B.B., M.Z., and A.R., unpublished data), the parameters LOH6q and mutation in NOTCH1 remain significant.