Immunologic reconstitution after transplantation (n = 17)
| Case no. . | Age at last follow-up . | Engraft-ment . | T cells . | B cells . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CD3+, cells/mm3 . | CD4+, cells/mm3 . | CD8+, cells/mm3 . | IRI+,index . | Mitogen response (PHA) . | TREC or equivalent* . | Naive/memory . | CD19+, cells/mm3 . | IVIg . | Antibody response . | |||||
| CD4+ CD45RA+, percentage of CD4+ . | CD4+ CD45RO+, percentage of CD4+ . | Tetanus . | Hib . | |||||||||||
| 1 | 4 y 3 mo | T | 980 | 430 | 490 | 0.9 | normal† | ND | NA | 68 | 100 | No | Good response | ND |
| 2 | 7 y 1 mo | Yes | 45%‡ | 14%‡ | 31%‡ | 0.5 | NA | ND | ND | ND | 40%‡ | No | ND | ND |
| 3 | 2 y 1 mo | Yes | 496 | 305 | 259 | 1.2 | Normal | ND | 25 | 85 | 365 | Yes | ND | ND |
| 4 | 7 mo | T | 900 | 288 | 612 | 0.5 | NA | ND | ND | ND | 576 | Yes | ND | ND |
| 5 | 7 mo | T | 174 | NA | NA | NA | Normal | NA | NA | NA | NA | Yes | ND | ND |
| 6 | 12 y 3 mo | T | 786 | 348 | 433 | 0.8 | Normal | 0 | NA | NA | NA | No | Good response | Good response |
| 7 | 10 mo | No | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 573 | Yes | ND | ND | |
| 8 | 8 mo | T | 464 | NA | NA | NA | ND | 0 | NA | NA | 590 | Yes | ND | ND |
| 9 | 10 mo | T | 504 | 163 | 293 | 0.6 | ND | 0 | NA | NA | 2236 | Yes | ND | ND |
| 10 | NA | No | 0§ | 0 | 0 | 0 | 50% | NA | NA | NA | 1379 | Yes | ND | ND |
| 11 | 12.5 y | T | 644 | 225 | 419 | 0.5 | 50% | 0 | NA | NA | 243 | No | Good response | Good response |
| 12 | 4 y 6 mo | T | 806 | 265 | 472 | 0.6 | Normal | 0 | 2 | 99 | 219 | Yes | Good response | ND |
| 13 | 1 y 3 mo | T | 1342 | 1065 | 276 | 3.9 | ND | ND | 8 | 84 | 0 | Yes | ND | ND |
| 14 | 2 y | T | 868 | 742 | 56 | 13.3 | Normal | ND | 6 | 95 | 378 | Yes | NA | NA |
| 15 | 1 y 5 mo | Yes | 196 | 160 | 39 | 4.1 | Normal | 0 | NA | NA | 273 | No | ND | ND |
| 16 | 5 y 7 mo | T | 1224 | 782 | 238 | 3.3 | 77% | ND | 1 | 99 | 1786 | No | Good response | Good response |
| 17 | 1 y 2 mo | Yes | 195 | 176 | 12 | 14.7 | 33% | ND | NA | NA | 422 | Yes | ND | ND |
| Case no. . | Age at last follow-up . | Engraft-ment . | T cells . | B cells . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CD3+, cells/mm3 . | CD4+, cells/mm3 . | CD8+, cells/mm3 . | IRI+,index . | Mitogen response (PHA) . | TREC or equivalent* . | Naive/memory . | CD19+, cells/mm3 . | IVIg . | Antibody response . | |||||
| CD4+ CD45RA+, percentage of CD4+ . | CD4+ CD45RO+, percentage of CD4+ . | Tetanus . | Hib . | |||||||||||
| 1 | 4 y 3 mo | T | 980 | 430 | 490 | 0.9 | normal† | ND | NA | 68 | 100 | No | Good response | ND |
| 2 | 7 y 1 mo | Yes | 45%‡ | 14%‡ | 31%‡ | 0.5 | NA | ND | ND | ND | 40%‡ | No | ND | ND |
| 3 | 2 y 1 mo | Yes | 496 | 305 | 259 | 1.2 | Normal | ND | 25 | 85 | 365 | Yes | ND | ND |
| 4 | 7 mo | T | 900 | 288 | 612 | 0.5 | NA | ND | ND | ND | 576 | Yes | ND | ND |
| 5 | 7 mo | T | 174 | NA | NA | NA | Normal | NA | NA | NA | NA | Yes | ND | ND |
| 6 | 12 y 3 mo | T | 786 | 348 | 433 | 0.8 | Normal | 0 | NA | NA | NA | No | Good response | Good response |
| 7 | 10 mo | No | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 573 | Yes | ND | ND | |
| 8 | 8 mo | T | 464 | NA | NA | NA | ND | 0 | NA | NA | 590 | Yes | ND | ND |
| 9 | 10 mo | T | 504 | 163 | 293 | 0.6 | ND | 0 | NA | NA | 2236 | Yes | ND | ND |
| 10 | NA | No | 0§ | 0 | 0 | 0 | 50% | NA | NA | NA | 1379 | Yes | ND | ND |
| 11 | 12.5 y | T | 644 | 225 | 419 | 0.5 | 50% | 0 | NA | NA | 243 | No | Good response | Good response |
| 12 | 4 y 6 mo | T | 806 | 265 | 472 | 0.6 | Normal | 0 | 2 | 99 | 219 | Yes | Good response | ND |
| 13 | 1 y 3 mo | T | 1342 | 1065 | 276 | 3.9 | ND | ND | 8 | 84 | 0 | Yes | ND | ND |
| 14 | 2 y | T | 868 | 742 | 56 | 13.3 | Normal | ND | 6 | 95 | 378 | Yes | NA | NA |
| 15 | 1 y 5 mo | Yes | 196 | 160 | 39 | 4.1 | Normal | 0 | NA | NA | 273 | No | ND | ND |
| 16 | 5 y 7 mo | T | 1224 | 782 | 238 | 3.3 | 77% | ND | 1 | 99 | 1786 | No | Good response | Good response |
| 17 | 1 y 2 mo | Yes | 195 | 176 | 12 | 14.7 | 33% | ND | NA | NA | 422 | Yes | ND | ND |
Data are given for the last follow-up.
IRI indicates immunoregulatory index; PHA, phytohemagglutinin; IVIg, intravenous immunoglobulin; NA, data not available; T, T cells; Hib, Haemophilus influenzae b; and ND, not done.
TREC equivalent = CD4+CD45RA+CD27+ or CD3+CD45RA+CD62L.
Also stimulated with anti-CD3, CD28.
No absolute cell count available.
Data after first transplantation; details after the second one are not available.