Cooperating genetic changes in leukemic mice belonging to groups 1 and 2
| Group/tumor ID . | Genotype . | Stem cell* . | Proliferation* . | Tumor suppressor* . | Novel . | Others . |
|---|---|---|---|---|---|---|
| Group 1: myeloid leukemia | ||||||
| 696 | Runx1−/− | Gfi1/Evi5 (c) | c-Myc (c) | |||
| 807 | Runx1−/− | Ncoa2‡ | Ing4 | Rbm34 | ||
| 966 | Runx1−/− | Evi1 (c) | IL6st | |||
| 714 | Runx1−/− | Gfi1/Evi5 (c) | Cyclin D3 (c), Cyclin D2 (c) | Dab2‡ | Lfng, Swap70 | |
| 708 | Runx1−/− | Evi1 (c) | Pik3cd | Mapk9 (Jnk) | Slis7 (c) | Tmem23‡ |
| Group 2: biphenotypic leukemia | ||||||
| 691† | Runx1−/− | |||||
| 813 | Runx1−/− | Gfi1/Evi5 (c)‡ | Slis6 (c) | Arhgap25 | ||
| 775 | Runx1−/− | c-Myc (c) | Gimap7, Ak1 | |||
| 770 | Runx1−/− | Cyclin D3 (c), Sema4d | Gadd45 | Slis7 (c) | Cspg4, mSin3a | |
| 641 | Runx1−/− | Cyclin D3 (c), Cyclin D2 (c) | Stag1§ | Slis8 (c) | Ang 2 | |
| 819 | Runx1−/− | Gfi1/Evi5 (c) | Stx4a, Negr1 | |||
| 821 | Runx1−/− | |||||
| 779 | Runx1−/− | c-Myc (c) | Nkd1 | Slis8 (c) | ||
| 982 | Runx1−/− | Gfi1/Evi5 (c) | Stag1§ | Slis6 (c) | Limk2 | |
| 972 | Runx1−/− | Ppfibp1 | ||||
| 969 | Runx1−/− | Gfi1/Evi5 (c), Evi1 (c) | N-myc (c)‡, Cyclin D1 (c) | Mad1l1‡ | Rabggtb | |
| 948 | Runx1−/− | Gfi1/Evi5 (c) | N-myc (c)‡ | Stk16, Mdm4 | ||
| 974 | Runx1−/− | Lmo2‖ | c-Myc (c), Cyclin D3 (c), Lef1 | Ldb1 | ||
| 693 | Runx1+/+ | Tnfrsf191 | Tspan32 | |||
| 690 | Runx1+/+ | Lmo2‖ | Foxp1 | |||
| 663 | Runx1+/+ | Gfi1/Evi5 (c) | Pip5k2a‡ | Ugcg | ||
| Unclassified‡ | ||||||
| 2 | Runx1−/− | Gfi1/Evi5 (c) | N-myc (c)‡, Sept9, Pim2 | |||
| 4 | Runx1−/− | Gfi1/Evi5 (c)‡, Hes1 | IL2 | Slis6 (c) | Birc4 | |
| 998 | Runx1−/− | Gfi1/Evi5 (c) | ||||
| 838 | Runx1−/− | Gfi1/Evi5 (c)‡ |
| Group/tumor ID . | Genotype . | Stem cell* . | Proliferation* . | Tumor suppressor* . | Novel . | Others . |
|---|---|---|---|---|---|---|
| Group 1: myeloid leukemia | ||||||
| 696 | Runx1−/− | Gfi1/Evi5 (c) | c-Myc (c) | |||
| 807 | Runx1−/− | Ncoa2‡ | Ing4 | Rbm34 | ||
| 966 | Runx1−/− | Evi1 (c) | IL6st | |||
| 714 | Runx1−/− | Gfi1/Evi5 (c) | Cyclin D3 (c), Cyclin D2 (c) | Dab2‡ | Lfng, Swap70 | |
| 708 | Runx1−/− | Evi1 (c) | Pik3cd | Mapk9 (Jnk) | Slis7 (c) | Tmem23‡ |
| Group 2: biphenotypic leukemia | ||||||
| 691† | Runx1−/− | |||||
| 813 | Runx1−/− | Gfi1/Evi5 (c)‡ | Slis6 (c) | Arhgap25 | ||
| 775 | Runx1−/− | c-Myc (c) | Gimap7, Ak1 | |||
| 770 | Runx1−/− | Cyclin D3 (c), Sema4d | Gadd45 | Slis7 (c) | Cspg4, mSin3a | |
| 641 | Runx1−/− | Cyclin D3 (c), Cyclin D2 (c) | Stag1§ | Slis8 (c) | Ang 2 | |
| 819 | Runx1−/− | Gfi1/Evi5 (c) | Stx4a, Negr1 | |||
| 821 | Runx1−/− | |||||
| 779 | Runx1−/− | c-Myc (c) | Nkd1 | Slis8 (c) | ||
| 982 | Runx1−/− | Gfi1/Evi5 (c) | Stag1§ | Slis6 (c) | Limk2 | |
| 972 | Runx1−/− | Ppfibp1 | ||||
| 969 | Runx1−/− | Gfi1/Evi5 (c), Evi1 (c) | N-myc (c)‡, Cyclin D1 (c) | Mad1l1‡ | Rabggtb | |
| 948 | Runx1−/− | Gfi1/Evi5 (c) | N-myc (c)‡ | Stk16, Mdm4 | ||
| 974 | Runx1−/− | Lmo2‖ | c-Myc (c), Cyclin D3 (c), Lef1 | Ldb1 | ||
| 693 | Runx1+/+ | Tnfrsf191 | Tspan32 | |||
| 690 | Runx1+/+ | Lmo2‖ | Foxp1 | |||
| 663 | Runx1+/+ | Gfi1/Evi5 (c) | Pip5k2a‡ | Ugcg | ||
| Unclassified‡ | ||||||
| 2 | Runx1−/− | Gfi1/Evi5 (c) | N-myc (c)‡, Sept9, Pim2 | |||
| 4 | Runx1−/− | Gfi1/Evi5 (c)‡, Hes1 | IL2 | Slis6 (c) | Birc4 | |
| 998 | Runx1−/− | Gfi1/Evi5 (c) | ||||
| 838 | Runx1−/− | Gfi1/Evi5 (c)‡ |
Table shows the genes near CISs or RISs that may have a role in oncogenesis based on their known or predicted function. (c) indicates CISs identified in this study. Leukemia cases in each group are arranged in ascending order of latency.
Known or predicted function.
RIS information is not available for this sample.
Genes with retroviral integrations inside the gene.
Unclassified leukemia cases, which could belong to group 1 or 2; they showed early onset of disease and no enlargement of thymus/lymph node, and flow cytometric data are not available.
Gene near 2 RISs that cannot be classified as CISs based on definition.