Table 3 Human ABCG5/ABCG8 transgenic... | American Society of Hematology

Table 3

Human ABCG5/ABCG8 transgenic rescue of the trac mutation

Genotype	+/? +/+	+/? +/TgN*	trac/trac +/+	trac/trac +/TgN*
Genotype	N = 4	N = 3	N = 3	N = 5
Platelet no., × 10⁹/L	1048 ± 110	1165 ± 125	248 ± 58	1102 ± 79†
Platelet volume, fL	7.1 ± 0.7	7.5 ± 1.2	20.5 ± 2.4	6.9 ± 1.0†

Genotype	+/? +/+	+/? +/TgN*	trac/trac +/+	trac/trac +/TgN*
Genotype	N = 4	N = 3	N = 3	N = 5
Platelet no., × 10⁹/L	1048 ± 110	1165 ± 125	248 ± 58	1102 ± 79†
Platelet volume, fL	7.1 ± 0.7	7.5 ± 1.2	20.5 ± 2.4	6.9 ± 1.0†

TgN is an abbreviation of genotype for the ABCG5- and ABCG8-linked human transgenes.

Platelet counts and volumes significantly different from those of trac/trac +/+ (nontransgenic) mice at P < .001.