Table 1

Steady-state hematopoiesis in pIC-induced mice

GenotypeRBC PB, ×1012/LWBC PB, ×109/LCells/femur, ×106LSK/femur, ×103Cells/spleen, ×106RBC spleen,† ×109
WT (n = 3-7) 8.3 ± 0.4 7.5 ± 3.2 41.7 ± 8.3 132.1 ± 41.0 207.0 ± 80.8 32.5 ± 5.0 
Smad1 KO (n = 3) 8.3 ± 0.2 10.8 ± 1.8 39.3 ± 2.9 132.7 ± 23.9 222.7 ± 39.6 NA 
Smad1/5 KO (n = 4) 1.8 ± 0.5* 8.1 ± 1.8 38.4 ± 6.9 NA 511.5 ± 164.3* 77.5 ± 9.6* 
GenotypeRBC PB, ×1012/LWBC PB, ×109/LCells/femur, ×106LSK/femur, ×103Cells/spleen, ×106RBC spleen,† ×109
WT (n = 3-7) 8.3 ± 0.4 7.5 ± 3.2 41.7 ± 8.3 132.1 ± 41.0 207.0 ± 80.8 32.5 ± 5.0 
Smad1 KO (n = 3) 8.3 ± 0.2 10.8 ± 1.8 39.3 ± 2.9 132.7 ± 23.9 222.7 ± 39.6 NA 
Smad1/5 KO (n = 4) 1.8 ± 0.5* 8.1 ± 1.8 38.4 ± 6.9 NA 511.5 ± 164.3* 77.5 ± 9.6* 

Data are mean ± SD.

RBC indicates red blood cell count; WBC, white blood cell count; PB, peripheral blood; and NA, not applicable.

*

P < .05.

Spleens suspended in 10 mL PBS.