Table 1 Composition and inhibitory... | American Society of Hematology

Table 1

Composition and inhibitory activity of carbohydrates

Molecule	Uronate type	Uronate sulfation* (%)	Glucosamine sulfation* (%)	Degree of sulfation†	IC₅₀
Heparin	IdoA	2S, 84	NS, 95, 6S, 90	2.6	19
Heparin, partially de-N-sulfated	IdoA	2S, 84	NS, 80, 6S, 90	2.5	74
Heparin, de-N-sulfated	IdoA	2S, 83	NS, 8, 6S, 92	1.8	>100
Heparin, de-N/O-sulfated	IdoA	0	0	0	>100
Heparin, de-6-O-sulfated	IdoA	2S, 60	NS, 95, 6S, 9	1.6	373
Heparin, de-2-O-sulfated	IdoA	2S, 5	NS, 95, 6S, 88	1.9	123
K5-NS	GlcA	0	NS, 100	1	>100
K5-OS-L	GlcA	2S, 10	6S, 90	1.4	>100
K5-OS-H	GlcA	2,3-diS, 100	6S,‡ 100	3	20.2
K5-NSOS-L	GlcA	2S, 10	NS, 100, 6S, 90	2	56
K5-NSOS-H	Glc A	2S, 30, 2,3-diS, 70	NS, 100, 6S, 100	3.7	7.4
EK5-NSOS-L	IdoA/GlcA 1:1	2S, 10	NS, 100, 6S, 90	2	103
EK5-NSOS-H	IdoA/GlcA 1:1	2S, 30, 2,3-diS, 70	NS, 100, 6S, 100	3.7	103

Molecule	Uronate type	Uronate sulfation* (%)	Glucosamine sulfation* (%)	Degree of sulfation†	IC₅₀
Heparin	IdoA	2S, 84	NS, 95, 6S, 90	2.6	19
Heparin, partially de-N-sulfated	IdoA	2S, 84	NS, 80, 6S, 90	2.5	74
Heparin, de-N-sulfated	IdoA	2S, 83	NS, 8, 6S, 92	1.8	>100
Heparin, de-N/O-sulfated	IdoA	0	0	0	>100
Heparin, de-6-O-sulfated	IdoA	2S, 60	NS, 95, 6S, 9	1.6	373
Heparin, de-2-O-sulfated	IdoA	2S, 5	NS, 95, 6S, 88	1.9	123
K5-NS	GlcA	0	NS, 100	1	>100
K5-OS-L	GlcA	2S, 10	6S, 90	1.4	>100
K5-OS-H	GlcA	2,3-diS, 100	6S,‡ 100	3	20.2
K5-NSOS-L	GlcA	2S, 10	NS, 100, 6S, 90	2	56
K5-NSOS-H	Glc A	2S, 30, 2,3-diS, 70	NS, 100, 6S, 100	3.7	7.4
EK5-NSOS-L	IdoA/GlcA 1:1	2S, 10	NS, 100, 6S, 90	2	103
EK5-NSOS-H	IdoA/GlcA 1:1	2S, 30, 2,3-diS, 70	NS, 100, 6S, 100	3.7	103

Data on sulfation levels are based on information provided by manufacturers and published data.²³ The position and degree (%) of sulfation is indicated.

†

The average number of sulfate groups per disaccharide unit.

‡

3-O-sulfation of the glucosamine is also present (level of sulfation is unknown).

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