Distribution, ORs, and 95% CIs for selected exposures in familial WM patients and their unaffected blood relatives
| Exposure . | Frequency of reported exposure, no. (%) . | OR (95% CI)* . | LRT . | |||||
|---|---|---|---|---|---|---|---|---|
| Multiple-case WM, n = 57† . | Mixed WM/BCD, n = 46 . | All familial WM, n = 103 . | Unaffected relatives, n = 272 . | Cases vs controls: multiple-case families . | Cases vs unaffected: mixed WM/BCD families . | All familial WM vs all controls . | ||
| Smoking, ever | 30 (53.6) | 26 (57.8) | 56 (55.4) | 122 (45.2) | 1.41 (0.68-2.91) | 1.38 (0.70-2.73) | 1.36 (0.83-2.20) | 0.9 |
| Alcohol, ever | 46 (80.7) | 38 (82.6) | 84 (81.6) | 206 (76.0) | 2.21 (0.83-5.90) | 1.30 (0.49-3.48) | 1.74 (0.84-3.59) | 0.9 |
| Farming | 11 (19.6) | 10 (22.2) | 21 (20.8) | 24 (8.8) | 1.52 (0.70-3.31) | 5.52 (1.92-15.88)‡ | 2.70 (1.34-5.43)‡ | 0.06 |
| Pesticides | 9 (16.1) | 9 (19.6) | 18 (17.6) | 26 (9.6) | 2.22 (0.98-5.04) | 3.10 (1.31-7.35)‡ | 2.83 (1.56-5.11)‡ | 0.4 |
| Livestock | 10 (17.8) | 6 (13.3) | 16 (15.8) | 34 (12.6) | 1.06 (0.44-2.55) | 0.99 (0.35-2.83) | 1.07 (0.55-2.10) | 0.8 |
| Organic solvents | 14 (27.4) | 9 (20.4) | 23 (24.2) | 30 (12.2) | 4.21 (1.69-10.51)‡ | 1.14 (0.49-2.63) | — | 0.05 |
| Wood dust | 11 (23.4) | 7 (17.1) | 18 (20.4) | 28 (11.7) | 2.57 (1.09-6.06)‡ | 3.21 (1.16-8.85)‡ | 2.86 (1.54-5.33)‡ | 0.6 |
| Asbestos | 5 (11.1) | 5 (12.8) | 10 (11.9) | 9 (3.9) | 1.97 (0.41-9.56) | 4.88 (1.07-22.20)‡ | 2.64 (0.85-8.19) | 0.5 |
| Hair dye | 10 (21.3) | 8 (18.6) | 18 (20.0) | 38 (15.8) | 2.11 (0.96-4.66) | 1.16 (0.48-2.81) | 1.53 (0.83-2.82) | 0.5 |
| Radiation-related occupation | 2 (3.6) | 4 (8.9) | 6 (5.9) | 18 (6.8) | 0.58 (0.06-5.13) | 0.86 (0.26-2.82) | 0.74 (0.25-2.21) | 0.8 |
| Therapeutic radiation | 2 (3.5) | 2 (4.3) | 4 (3.9) | 21 (7.8) | 0.41 (0.08-1.99) | 0.16 (0.02-1.07) | 0.21 (0.05-0.81)‡ | 0.3 |
| Exposure . | Frequency of reported exposure, no. (%) . | OR (95% CI)* . | LRT . | |||||
|---|---|---|---|---|---|---|---|---|
| Multiple-case WM, n = 57† . | Mixed WM/BCD, n = 46 . | All familial WM, n = 103 . | Unaffected relatives, n = 272 . | Cases vs controls: multiple-case families . | Cases vs unaffected: mixed WM/BCD families . | All familial WM vs all controls . | ||
| Smoking, ever | 30 (53.6) | 26 (57.8) | 56 (55.4) | 122 (45.2) | 1.41 (0.68-2.91) | 1.38 (0.70-2.73) | 1.36 (0.83-2.20) | 0.9 |
| Alcohol, ever | 46 (80.7) | 38 (82.6) | 84 (81.6) | 206 (76.0) | 2.21 (0.83-5.90) | 1.30 (0.49-3.48) | 1.74 (0.84-3.59) | 0.9 |
| Farming | 11 (19.6) | 10 (22.2) | 21 (20.8) | 24 (8.8) | 1.52 (0.70-3.31) | 5.52 (1.92-15.88)‡ | 2.70 (1.34-5.43)‡ | 0.06 |
| Pesticides | 9 (16.1) | 9 (19.6) | 18 (17.6) | 26 (9.6) | 2.22 (0.98-5.04) | 3.10 (1.31-7.35)‡ | 2.83 (1.56-5.11)‡ | 0.4 |
| Livestock | 10 (17.8) | 6 (13.3) | 16 (15.8) | 34 (12.6) | 1.06 (0.44-2.55) | 0.99 (0.35-2.83) | 1.07 (0.55-2.10) | 0.8 |
| Organic solvents | 14 (27.4) | 9 (20.4) | 23 (24.2) | 30 (12.2) | 4.21 (1.69-10.51)‡ | 1.14 (0.49-2.63) | — | 0.05 |
| Wood dust | 11 (23.4) | 7 (17.1) | 18 (20.4) | 28 (11.7) | 2.57 (1.09-6.06)‡ | 3.21 (1.16-8.85)‡ | 2.86 (1.54-5.33)‡ | 0.6 |
| Asbestos | 5 (11.1) | 5 (12.8) | 10 (11.9) | 9 (3.9) | 1.97 (0.41-9.56) | 4.88 (1.07-22.20)‡ | 2.64 (0.85-8.19) | 0.5 |
| Hair dye | 10 (21.3) | 8 (18.6) | 18 (20.0) | 38 (15.8) | 2.11 (0.96-4.66) | 1.16 (0.48-2.81) | 1.53 (0.83-2.82) | 0.5 |
| Radiation-related occupation | 2 (3.6) | 4 (8.9) | 6 (5.9) | 18 (6.8) | 0.58 (0.06-5.13) | 0.86 (0.26-2.82) | 0.74 (0.25-2.21) | 0.8 |
| Therapeutic radiation | 2 (3.5) | 2 (4.3) | 4 (3.9) | 21 (7.8) | 0.41 (0.08-1.99) | 0.16 (0.02-1.07) | 0.21 (0.05-0.81)‡ | 0.3 |
OR indicates odds ratio; CI, confidence interval; WM, Waldenström macroglobulinemia; BCD, B-cell disorder; LRT, likelihood ratio test; and —, no relevant data.
Accounting for familial clustering among relatives and adjusted for age, sex, and family type (in all familial WM models).
Numbers and percentages may not sum to total because of missing data and rounding, respectively. Percentages are based on nonmissing values.
Parameters that differed significantly (P < .05) between groups. See “Results.”