Lymphocyte populations and function before HSCT and number of cells and immunoglobulin levels before transplantation
. | Pt 1 . | Pt 2 . | Pt 3 . | Pt 4 . | Pt 5 . | Pt 6 . | Pt 7 . | Pt 8 . | Pt 9 . | Pt 10 . | Pt 11 . | Pt 12 . | Pt 13 . | Pt 14 . | Pt 15 . | Pt 16 . |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age, y | < 1 (8 mo) | < 1 (8 mo) | 1.9 | 2 | 2.3 | 2.5 | 2.5 | 2.5 | 2.6 | 3 | 2.7 | 4.5 | 5.9 | 11 | 16.8 | 19 |
Lymphocytes/μL | 1778 | 275 | 314 | 600 | 1100 | 1250 | 1105 | 1100 | 1494 | 288 | 1087 | 723 | 312 | 2030 | 1000 | 267 |
CD3+/μL | 1120 | 290 | 113 | 50 | 300 | 99 | 105 | 655 | 638 | 72 | 886 | 583 | 154 | 1400 | 470 | 215 |
CD4+/μL | 960 | 210 | 85 | 40 | 100 | 62 | 101 | 545 | 417 | 55 | 336 | 389 | 138 | 832 | 340 | 168 |
CD8+/μL | 160 | 80 | 28 | 10 | 200 | 37 | 4 | 110 | 221 | 17 | 278 | 194 | 16 | 568 | 130 | 47 |
C19+/μL | 391 | 90 | 395 | 300 | 600 | 200 | 152 | 220 | 334 | 144 | 0* | 311 | 21 | 466 | 270 | 68 |
NK cells/μL | 243 | n.a. | 229 | n.a. | 221 | n.a. | 141 | 250 | 212 | 32 | 201 | 914 | 77 | 101 | 230 | 258 |
IgG | Low | Low | Normal | Normal | Low | Normal | Normal | Normal | Normal | Normal | Under IVIG | Normal | Low | Normal | Normal | Normal |
IgM | Normal | Low | Normal | Low | Normal | Normal | Normal | Normal | Normal | Normal | Low | Normal | Low | Low | Normal | Normal |
IgA | Normal | Low | Normal | Low | Low | Normal | Normal | Normal | Low | Normal | Low | Low | Low | Low | Normal | Normal |
Response to mitogens | n.a. | Poor | Absent | Absent | Poor | Poor | Absent | Poor | Normal | Poor | Poor | Poor | Poor | Poor | Absent | Poor |
. | Pt 1 . | Pt 2 . | Pt 3 . | Pt 4 . | Pt 5 . | Pt 6 . | Pt 7 . | Pt 8 . | Pt 9 . | Pt 10 . | Pt 11 . | Pt 12 . | Pt 13 . | Pt 14 . | Pt 15 . | Pt 16 . |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age, y | < 1 (8 mo) | < 1 (8 mo) | 1.9 | 2 | 2.3 | 2.5 | 2.5 | 2.5 | 2.6 | 3 | 2.7 | 4.5 | 5.9 | 11 | 16.8 | 19 |
Lymphocytes/μL | 1778 | 275 | 314 | 600 | 1100 | 1250 | 1105 | 1100 | 1494 | 288 | 1087 | 723 | 312 | 2030 | 1000 | 267 |
CD3+/μL | 1120 | 290 | 113 | 50 | 300 | 99 | 105 | 655 | 638 | 72 | 886 | 583 | 154 | 1400 | 470 | 215 |
CD4+/μL | 960 | 210 | 85 | 40 | 100 | 62 | 101 | 545 | 417 | 55 | 336 | 389 | 138 | 832 | 340 | 168 |
CD8+/μL | 160 | 80 | 28 | 10 | 200 | 37 | 4 | 110 | 221 | 17 | 278 | 194 | 16 | 568 | 130 | 47 |
C19+/μL | 391 | 90 | 395 | 300 | 600 | 200 | 152 | 220 | 334 | 144 | 0* | 311 | 21 | 466 | 270 | 68 |
NK cells/μL | 243 | n.a. | 229 | n.a. | 221 | n.a. | 141 | 250 | 212 | 32 | 201 | 914 | 77 | 101 | 230 | 258 |
IgG | Low | Low | Normal | Normal | Low | Normal | Normal | Normal | Normal | Normal | Under IVIG | Normal | Low | Normal | Normal | Normal |
IgM | Normal | Low | Normal | Low | Normal | Normal | Normal | Normal | Normal | Normal | Low | Normal | Low | Low | Normal | Normal |
IgA | Normal | Low | Normal | Low | Low | Normal | Normal | Normal | Low | Normal | Low | Low | Low | Low | Normal | Normal |
Response to mitogens | n.a. | Poor | Absent | Absent | Poor | Poor | Absent | Poor | Normal | Poor | Poor | Poor | Poor | Poor | Absent | Poor |
Pt indicates patient; IVIG, intravenous immunoglobulin; and n.a., not available.
Previous rituximab.