Percentages of the different erythroid subsets and B-cell compartment in the spleen after bone marrow transplantation
| . | Donor cells . | P . | |
|---|---|---|---|
| ERK1+/+ (n = 10) . | ERK1−/− (n = 14) . | ||
| Ter119+ cells | 31.18 ± 1.21 | 36.20 ± 1.67 | .032* |
| ProE population | 0.16 ± 0.02 | 0.60 ± 0.10 | < .001* |
| Ery.A population | 8.80 ± 1.40 | 20.29 ± 1.87 | < .001* |
| Ery.B population | 11.47 ± 1.26 | 25.55 ± 0.62 | < .001* |
| Ery.C population | 79.50 ± 2.59 | 53.86 ± 2.23 | < .001* |
| B220+ cells | 55.93 ± 1.05 | 52.76 ± 5.37 | .551 |
| . | Donor cells . | P . | |
|---|---|---|---|
| ERK1+/+ (n = 10) . | ERK1−/− (n = 14) . | ||
| Ter119+ cells | 31.18 ± 1.21 | 36.20 ± 1.67 | .032* |
| ProE population | 0.16 ± 0.02 | 0.60 ± 0.10 | < .001* |
| Ery.A population | 8.80 ± 1.40 | 20.29 ± 1.87 | < .001* |
| Ery.B population | 11.47 ± 1.26 | 25.55 ± 0.62 | < .001* |
| Ery.C population | 79.50 ± 2.59 | 53.86 ± 2.23 | < .001* |
| B220+ cells | 55.93 ± 1.05 | 52.76 ± 5.37 | .551 |
Bone marrow preparations from CD45.2 ERK1−/− or ERK1+/+ mice were used to repopulate irradiated CD45.1-marked wild-type recipients, in transplantation experiments. Four months after transplantation and for mice with greater than 90% CD45.2 engraftment, the percentage of total Ter119+ erythroblasts and those of the different erythroblast subpopulations in the spleen were determined as described in Figure 3. The percentage of B (B220+) cells was also determined. Data are mean percentage ± SEM.
Significantly different from ERK1+/+ value (P < .05).