Hematologic parameters of ERK1−/− mice
| . | ERK1+/+ (n = 20) . | ERK1−/− (n = 20) . | P . |
|---|---|---|---|
| RBC count, ×106/μL | 8.76 ± 0.22 | 9.27 ± 0.20 | .025* |
| HGB level, g/dL | 14.64 ± 0.33 | 15.65 ± 0.25 | .005* |
| HCT, % | 42.31 ± 1.04 | 45.5 ± 0.94 | .007* |
| MCV, fL | 48.37 ± 0.64 | 49.21 ± 0.43 | .046* |
| PLT count, ×103/μL | 636 ± 88.16 | 765 ± 73.96 | .256 |
| WBC count, ×103/μL | 7.86 ± 0.77 | 6.16 ± 0.34 | .079 |
| MONO count, ×103/μL | 2.63 ± 0.33 | 2.44 ± 0.24 | .633 |
| LYMP count, ×103/μL | 85.74 ± 1.78 | 89.07 ± 1.46 | .100 |
| . | ERK1+/+ (n = 20) . | ERK1−/− (n = 20) . | P . |
|---|---|---|---|
| RBC count, ×106/μL | 8.76 ± 0.22 | 9.27 ± 0.20 | .025* |
| HGB level, g/dL | 14.64 ± 0.33 | 15.65 ± 0.25 | .005* |
| HCT, % | 42.31 ± 1.04 | 45.5 ± 0.94 | .007* |
| MCV, fL | 48.37 ± 0.64 | 49.21 ± 0.43 | .046* |
| PLT count, ×103/μL | 636 ± 88.16 | 765 ± 73.96 | .256 |
| WBC count, ×103/μL | 7.86 ± 0.77 | 6.16 ± 0.34 | .079 |
| MONO count, ×103/μL | 2.63 ± 0.33 | 2.44 ± 0.24 | .633 |
| LYMP count, ×103/μL | 85.74 ± 1.78 | 89.07 ± 1.46 | .100 |
All measurements were carried out on ERK1−/− mice at 2 to 4 months of age and on wild-type controls (ERK1+/+) from the same mouse colony. Data are mean ± SEM.
RBC indicates red blood cell; HGB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; PLT, platelet; WBC, white blood cell; MONO, monocyte; and LYMP, lymphocyte.
Significantly different from ERK1+/+ value (P < .05).