Comparison of mouse strain characteristics
| Mouse strain . | Hb, g/dL . | Serum iron, μg/dL . | Baseline hepcidin, ng/mL . | BA-induced hepcidin, ng/mL . | ||
|---|---|---|---|---|---|---|
| mHepc1 . | hHepc . | mHepc1 . | hHepc . | |||
| C57BL/6 | 15.0 ± 0.1 | 167 ± 6 | 175 ± 9 | 0 | 617 ± 73 | 0 |
| Hep1 knock-in | 15.0 ± 0.1 | 340 ± 6 | 0 | 113 ± 16 | 0 | 329 ± 26 |
| Hep1 control | 15.2 ± 0.3 | 207 ± 16 | 171 ± 25 | 0 | ND | 0 |
| Hep2 knock-in | 15.8 ± 0.1 | 330 ± 15 | 0 | 106 ± 35 | 0 | 428 ± 49 |
| Hep2 control | 14.9 ± 0.2 | 260 ± 6 | 210 ± 25 | 0 | 368 ± 64 | 0 |
| Mouse strain . | Hb, g/dL . | Serum iron, μg/dL . | Baseline hepcidin, ng/mL . | BA-induced hepcidin, ng/mL . | ||
|---|---|---|---|---|---|---|
| mHepc1 . | hHepc . | mHepc1 . | hHepc . | |||
| C57BL/6 | 15.0 ± 0.1 | 167 ± 6 | 175 ± 9 | 0 | 617 ± 73 | 0 |
| Hep1 knock-in | 15.0 ± 0.1 | 340 ± 6 | 0 | 113 ± 16 | 0 | 329 ± 26 |
| Hep1 control | 15.2 ± 0.3 | 207 ± 16 | 171 ± 25 | 0 | ND | 0 |
| Hep2 knock-in | 15.8 ± 0.1 | 330 ± 15 | 0 | 106 ± 35 | 0 | 428 ± 49 |
| Hep2 control | 14.9 ± 0.2 | 260 ± 6 | 210 ± 25 | 0 | 368 ± 64 | 0 |
Mean ± SEM values for mice illustrating serum iron, Hb, and serum hepcidin. BA-induced hepcidin values were measured 6 hours after BA administration.
Hb indicates hemglobulin; BA, Brucella abortus; Hep, hepcidin; hHepc, human hepcidin; mHepc, mouse hepcidin; and ND, values not determined experimentally.