Patient characteristics: patients in remission (n = 102)
| Characteristic . | No. . |
|---|---|
| Patient-related factors | |
| Age at transplantation, y (range) | 8.7 (0.64-16) |
| Sex, male/female | 70/32 |
| CMV serology | |
| Negative | 40 |
| Positive | 59 |
| Not known | 3 |
| Donor-related factors | |
| Age at transplantation, y (range) | 36.6 (18-53.8) |
| Sex, male/female | 55/47 |
| Female donor to male recipient | |
| No | 71 |
| Yes | 31 |
| CMV serology | |
| Negative | 32 |
| Positive | 61 |
| Not known | 9 |
| Disease-related factors | |
| WBC at diagnosis × 109/L | 27.2 (1.9-517) |
| Immunophenotype | |
| B | 84 |
| T | 11 |
| Biphenotypic | 2 |
| Not known | 5 |
| Cytogenetic | |
| No Ph+ | 63 |
| Ph+ or t(4;11) | 24 |
| Not performed/not available | 15 |
| Status at transplantation | |
| CR1 | 22 (22%) |
| CR2 | 48 (47%) |
| CR3 | 32 (31%) |
| Median time from first diagnosis to transplantation, mo | |
| CR1 | 6 (3-16) |
| CR2 | 32 (6-80) |
| CR3 | 57 (11-141) |
| Previous autologous transplantation | |
| No | 94 |
| Yes | 8 |
| Transplant-related factors | |
| Year of transplantation | |
| 1995 | 4 |
| 1996 | 6 |
| 1997 | 5 |
| 1998 | 14 |
| 1999 | 11 |
| 2000 | 17 |
| 2001 | 10 |
| 2002 | 10 |
| 2003 | 14 |
| 2004 | 11 |
| Median, y | 2000 |
| Donor type | |
| Mother | 44 |
| Father | 51 |
| Brother | 5 |
| Sister | 2 |
| No. of antigen mismatches in HLA-A, -B, -DR | |
| 2 | 34 |
| 3 | 68 |
| KIR mismatches between donor and recipients | |
| Yes | 25 |
| No | 41 |
| Not known | 36 |
| Cell source | |
| BM | 6 |
| PB | 96 |
| In vitro T-cell depletion, device used | |
| CliniMacs | 79 |
| Baxter | 12 |
| Cellpro | 6 |
| Negative T depletion | 5 |
| Serotherapy with ATG or ALG | |
| No | 22 |
| Yes | 76 |
| Not known | 4 |
| Use of monoclonal antibodies | |
| No | 57 |
| Yes | 44 |
| Not known | 1 |
| Total body irradiation | |
| No | 24 |
| Yes | 78 |
| No. of CD34+ × 106/kg body weight | |
| All | 12.33 (1.36-95.2) |
| PB only | 12.4 (1.9-67) |
| No. of CD3+ × 106/kg body weight* | |
| All | 0.05 (0-129) |
| PB only | 0.045 (0-128.7) |
| Donor lymphocyte infusion performed | |
| No | 86 |
| Yes | 16 |
| Characteristic . | No. . |
|---|---|
| Patient-related factors | |
| Age at transplantation, y (range) | 8.7 (0.64-16) |
| Sex, male/female | 70/32 |
| CMV serology | |
| Negative | 40 |
| Positive | 59 |
| Not known | 3 |
| Donor-related factors | |
| Age at transplantation, y (range) | 36.6 (18-53.8) |
| Sex, male/female | 55/47 |
| Female donor to male recipient | |
| No | 71 |
| Yes | 31 |
| CMV serology | |
| Negative | 32 |
| Positive | 61 |
| Not known | 9 |
| Disease-related factors | |
| WBC at diagnosis × 109/L | 27.2 (1.9-517) |
| Immunophenotype | |
| B | 84 |
| T | 11 |
| Biphenotypic | 2 |
| Not known | 5 |
| Cytogenetic | |
| No Ph+ | 63 |
| Ph+ or t(4;11) | 24 |
| Not performed/not available | 15 |
| Status at transplantation | |
| CR1 | 22 (22%) |
| CR2 | 48 (47%) |
| CR3 | 32 (31%) |
| Median time from first diagnosis to transplantation, mo | |
| CR1 | 6 (3-16) |
| CR2 | 32 (6-80) |
| CR3 | 57 (11-141) |
| Previous autologous transplantation | |
| No | 94 |
| Yes | 8 |
| Transplant-related factors | |
| Year of transplantation | |
| 1995 | 4 |
| 1996 | 6 |
| 1997 | 5 |
| 1998 | 14 |
| 1999 | 11 |
| 2000 | 17 |
| 2001 | 10 |
| 2002 | 10 |
| 2003 | 14 |
| 2004 | 11 |
| Median, y | 2000 |
| Donor type | |
| Mother | 44 |
| Father | 51 |
| Brother | 5 |
| Sister | 2 |
| No. of antigen mismatches in HLA-A, -B, -DR | |
| 2 | 34 |
| 3 | 68 |
| KIR mismatches between donor and recipients | |
| Yes | 25 |
| No | 41 |
| Not known | 36 |
| Cell source | |
| BM | 6 |
| PB | 96 |
| In vitro T-cell depletion, device used | |
| CliniMacs | 79 |
| Baxter | 12 |
| Cellpro | 6 |
| Negative T depletion | 5 |
| Serotherapy with ATG or ALG | |
| No | 22 |
| Yes | 76 |
| Not known | 4 |
| Use of monoclonal antibodies | |
| No | 57 |
| Yes | 44 |
| Not known | 1 |
| Total body irradiation | |
| No | 24 |
| Yes | 78 |
| No. of CD34+ × 106/kg body weight | |
| All | 12.33 (1.36-95.2) |
| PB only | 12.4 (1.9-67) |
| No. of CD3+ × 106/kg body weight* | |
| All | 0.05 (0-129) |
| PB only | 0.045 (0-128.7) |
| Donor lymphocyte infusion performed | |
| No | 86 |
| Yes | 16 |
CMV indicates cytomegalovirus; WBC, white blood cell count; CR, complete remission; Ph+, Philadelphia chromosome positive; ATG, antithymocyte globulin; ALG, antilymphocyte globulin; PB, peripheral blood; and BM, bone marrow.
n = 10 not known.