Current ALPS diagnostic and study inclusion/exclusion criteria
| Current diagnostic criteria for ALPS . |
|---|
| Chronic nonmalignant lymphoproliferation |
| Elevated peripheral blood DNTs |
| Defective in vitro Fas-mediated apoptosis |
| MUST MEET ALL THREE CRITERIA FOR DIAGNOSIS* |
| Supportive but not diagnostic: |
| Genetic mutation (FAS, FASL, CASP10, NRAS) |
| Autoimmunity |
| Family history |
| Histopathology |
| Current diagnostic criteria for ALPS . |
|---|
| Chronic nonmalignant lymphoproliferation |
| Elevated peripheral blood DNTs |
| Defective in vitro Fas-mediated apoptosis |
| MUST MEET ALL THREE CRITERIA FOR DIAGNOSIS* |
| Supportive but not diagnostic: |
| Genetic mutation (FAS, FASL, CASP10, NRAS) |
| Autoimmunity |
| Family history |
| Histopathology |
| Study inclusion and exclusion criteria . |
|---|
| Inclusion criteria |
| Age 1-21 y |
| Diagnosis of Evans syndrome by treating physician |
| Documented autoimmune cytopenias |
| Either 2 or 3 cell types (RBCs, WBC, platelets), or |
| Autoimmune thrombocytopenia and strongly positive direct antiglobulin test |
| Exclusion criteria |
| Autoimmune disease |
| Systemic lupus erythematosus |
| Juvenile idiopathic arthritis |
| Malignancy |
| Immunosuppression after solid organ transplantation |
| Concurrent immunomodulating medications, except for low-dose corticosteroids (≤ 0.5 mg/kg/d)† |
| Study inclusion and exclusion criteria . |
|---|
| Inclusion criteria |
| Age 1-21 y |
| Diagnosis of Evans syndrome by treating physician |
| Documented autoimmune cytopenias |
| Either 2 or 3 cell types (RBCs, WBC, platelets), or |
| Autoimmune thrombocytopenia and strongly positive direct antiglobulin test |
| Exclusion criteria |
| Autoimmune disease |
| Systemic lupus erythematosus |
| Juvenile idiopathic arthritis |
| Malignancy |
| Immunosuppression after solid organ transplantation |
| Concurrent immunomodulating medications, except for low-dose corticosteroids (≤ 0.5 mg/kg/d)† |