Table 3 Sequences at the reciprocal... | American Society of Hematology

Table 3

Sequences at the reciprocal breakpoint junctions of the DH-MALT1 fusion products

Cases	D_H	Processing of ends*	D_H sequence (14q32)	De novo nucleotide additions†	MALT1 sequence (18q21)‡	Processing of ends*
Germline	D2-15		AGGATATTGTAGTGGTGGTAGCTGCTACTCC		²⁷⁵⁵⁶GCAACCTCTCGTGTGCATACGAGTTAAATG²⁷⁵⁸⁵
Germline	D2-21		AGCATATTGTGGTGGTGACTGCTATTCC
Case 1	D2-15	−29 bp	CCAGTAGGGACAGGAGGATTTTGTGGGGGCTCGTGTCACTGTGAG	CAGAACCCGT	GTGTGCATACGAGTTAAATG²⁷⁵⁸⁵	+8 bp
Case 2	D2-21	−13 bp	AGCATATTGTGGTGG	AAACT	CATACGAGTTAAATG²⁷⁵⁸⁵	−4 bp

Cases	D_H	Processing of ends*	D_H sequence (14q32)	De novo nucleotide additions†	MALT1 sequence (18q21)‡	Processing of ends*
Germline	D2-15		AGGATATTGTAGTGGTGGTAGCTGCTACTCC		²⁷⁵⁵⁶GCAACCTCTCGTGTGCATACGAGTTAAATG²⁷⁵⁸⁵
Germline	D2-21		AGCATATTGTGGTGGTGACTGCTATTCC
Case 1	D2-15	−29 bp	CCAGTAGGGACAGGAGGATTTTGTGGGGGCTCGTGTCACTGTGAG	CAGAACCCGT	GTGTGCATACGAGTTAAATG²⁷⁵⁸⁵	+8 bp
Case 2	D2-21	−13 bp	AGCATATTGTGGTGG	AAACT	CATACGAGTTAAATG²⁷⁵⁸⁵	−4 bp

Status of coding ends at IGH locus or MALT1 end processing (−bp indicates deletion; +bp, addition).

†

These sequences are deposited as GenBank Accession nos. GQ406057 and GQ406059.

‡

Numbers in superscript in the MALT1 sequence indicate the position of the first nucleotide in BAC clone RP11-126O1 according to GenBank sequence AC104971.

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