Table 1 Summary of EL4 liver metastasis... | American Society of Hematology

Table 1

Summary of EL4 liver metastasis in CXCL12- and Wnt5A-treated mice

Mouse group	High infiltration	Liver density			Wnt5A staining
Mouse group	High infiltration	Dense	Weakly affected	Affected	Negative	Weakly positive	Positive
Control	1/7	4*	2†	1	4*	2†	1
CXCL12	5/7	1*	2†	4	1*	2†	4
Wnt5A	6/7	0	1†	6	0	1†	6

Mouse group	High infiltration	Liver density			Wnt5A staining
Mouse group	High infiltration	Dense	Weakly affected	Affected	Negative	Weakly positive	Positive
Control	1/7	4*	2†	1	4*	2†	1
CXCL12	5/7	1*	2†	4	1*	2†	4
Wnt5A	6/7	0	1†	6	0	1†	6

EL4 cells infiltrate extensively into the liver in 5 of 7 and 6 of 7 CXCL12 and Wnt5A-treated animals, respectively. In control animals, only 1 of 7 demonstrate extensive EL4 infiltration into the liver, and in the 1 animal with high infiltration, EL4 cells are positive for Wnt5A. In livers with a high amount of infiltration, the liver architecture is severely compromised, appearing less dense, and Wnt5A staining is intense in the infiltrating EL4 cells.

Animals with no liver infiltration, in which the liver architecture remains dense.

†

Animals with low levels of infiltration, in which Wnt5A staining is quite weak in the infiltrating EL4 cells, and the liver architecture is only slightly affected.

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