Gene set enrichment analysis (GSEA) with 81 lymphoma-associated signatures in 147 t(14;18)-positive and 17 t(14;18)-negative FL cases
| Signatures . | Enriched in t(14;18)+ . | Enriched in t(14;18)− . | P . | FDR q value . |
|---|---|---|---|---|
| GCB | .01 | < 0.1 | ||
| Rosenwald et al, 2002, ref. 32 | Yes | No | ||
| Dave et al, 2006, ref. 34 | Yes | No | ||
| ABC | .02 | < 0.1 | ||
| Wright et al, 2003, ref. 35 | No | Yes | ||
| NFKB | ≤ .02 | ≤ 0.1 | ||
| Lam et al, 2005, ref. 36 | No | Yes | ||
| Post-GCB | .02 | < 0.1 | ||
| Shaffer et al, 2002, ref. 37 | No | Yes | ||
| Weller et al, 2004, ref. 38 | No | Yes | ||
| Wright et al, 2003, ref. 35 | No | Yes | ||
| IR1 | .03 | < 0.1 | ||
| Dave et al, 2004, ref. 6 | No | Yes | ||
| T cell | < .01 | 0.14 | ||
| McHugh et al, 2002, ref. 39 | No | Yes | ||
| Kovanen et al, 2003, ref. 40 | No | Yes | ||
| Cell cycle | < .01 | 0.2 | ||
| Shaffer et al, 2001, ref. 41 | No | Yes | ||
| Proliferation | ≤ .02 | ≤ 0.1 | ||
| Su et al, 2004, ref. 42 | No | Yes | ||
| Rosenwald et al, 2003, ref. 43 | No | Yes | ||
| Interferon | < .01 | < 0.1 | ||
| Baechler et al, 2003, ref. 44 | No | Yes |
| Signatures . | Enriched in t(14;18)+ . | Enriched in t(14;18)− . | P . | FDR q value . |
|---|---|---|---|---|
| GCB | .01 | < 0.1 | ||
| Rosenwald et al, 2002, ref. 32 | Yes | No | ||
| Dave et al, 2006, ref. 34 | Yes | No | ||
| ABC | .02 | < 0.1 | ||
| Wright et al, 2003, ref. 35 | No | Yes | ||
| NFKB | ≤ .02 | ≤ 0.1 | ||
| Lam et al, 2005, ref. 36 | No | Yes | ||
| Post-GCB | .02 | < 0.1 | ||
| Shaffer et al, 2002, ref. 37 | No | Yes | ||
| Weller et al, 2004, ref. 38 | No | Yes | ||
| Wright et al, 2003, ref. 35 | No | Yes | ||
| IR1 | .03 | < 0.1 | ||
| Dave et al, 2004, ref. 6 | No | Yes | ||
| T cell | < .01 | 0.14 | ||
| McHugh et al, 2002, ref. 39 | No | Yes | ||
| Kovanen et al, 2003, ref. 40 | No | Yes | ||
| Cell cycle | < .01 | 0.2 | ||
| Shaffer et al, 2001, ref. 41 | No | Yes | ||
| Proliferation | ≤ .02 | ≤ 0.1 | ||
| Su et al, 2004, ref. 42 | No | Yes | ||
| Rosenwald et al, 2003, ref. 43 | No | Yes | ||
| Interferon | < .01 | < 0.1 | ||
| Baechler et al, 2003, ref. 44 | No | Yes |
FDR indicates false discovery rate; GCB, germinal center B cell; and ABC, activated B cell.