Graft characteristics
| Graft characteristics . | Single unit (n = 84), median (range) . | Double unit (n = 93), median (range) . | P . |
|---|---|---|---|
| Total mononuclear cells/kg, ×107 | 3.3 (0.9-14.0) | 3.6 (1.1-6.5) | .17 |
| Smaller unit | 1.5 (0.5-2.7) | ||
| Larger unit | 2.1 (0.6-4.4) | ||
| CD34+ cell dose/kg, ×105 | 3.5 (0.4-34.8) | 4.5 (0.9-14.5) | .04 |
| Smaller unit | 1.5 (0.3-4.7) | ||
| Larger unit | 2.8 (0.5-10.6) | ||
| CD3+ cell dose/kg, ×107 | 1.0 (0.3-3.2) | 1.4 (0.5-3.1) | < .01 |
| Smaller unit | 0.5 (0.1-1.2) | ||
| Larger unit | 0.9 (0.3-2.0) | ||
| HLA match to recipient | |||
| Engrafting unit | .30 | ||
| 4/6 | 35 (42%) | 49 (53%) | |
| 5/6 | 42 (50%) | 36 (39%) | |
| 6/6 | 7 (8%) | 8 (9%) | |
| Highest amount of HLA disparity | .03 | ||
| 4/6 | 35 (42%) | 57 (65%) | |
| 5/6 | 42 (50%) | 30 (30%) | |
| 6/6 | 7 (8%) | 6 (6%) | |
| Lowest amount of HLA disparity | .72 | ||
| 4/6 | 35 (42%) | 25 (46%) | |
| 5/6 | 42 (50%) | 24 (44%) | |
| 6/6 | 7 (8%) | 5 (9%) |
| Graft characteristics . | Single unit (n = 84), median (range) . | Double unit (n = 93), median (range) . | P . |
|---|---|---|---|
| Total mononuclear cells/kg, ×107 | 3.3 (0.9-14.0) | 3.6 (1.1-6.5) | .17 |
| Smaller unit | 1.5 (0.5-2.7) | ||
| Larger unit | 2.1 (0.6-4.4) | ||
| CD34+ cell dose/kg, ×105 | 3.5 (0.4-34.8) | 4.5 (0.9-14.5) | .04 |
| Smaller unit | 1.5 (0.3-4.7) | ||
| Larger unit | 2.8 (0.5-10.6) | ||
| CD3+ cell dose/kg, ×107 | 1.0 (0.3-3.2) | 1.4 (0.5-3.1) | < .01 |
| Smaller unit | 0.5 (0.1-1.2) | ||
| Larger unit | 0.9 (0.3-2.0) | ||
| HLA match to recipient | |||
| Engrafting unit | .30 | ||
| 4/6 | 35 (42%) | 49 (53%) | |
| 5/6 | 42 (50%) | 36 (39%) | |
| 6/6 | 7 (8%) | 8 (9%) | |
| Highest amount of HLA disparity | .03 | ||
| 4/6 | 35 (42%) | 57 (65%) | |
| 5/6 | 42 (50%) | 30 (30%) | |
| 6/6 | 7 (8%) | 6 (6%) | |
| Lowest amount of HLA disparity | .72 | ||
| 4/6 | 35 (42%) | 25 (46%) | |
| 5/6 | 42 (50%) | 24 (44%) | |
| 6/6 | 7 (8%) | 5 (9%) |
Comparison of single versus double unit recipients with respect to TNC, CD34, and CD3 cell dose per kilogram. The HLA disparity between the UCB unit(s) and the host was compared for the engrafting unit, as well as the unit with the highest and lowest HLA disparity (for double recipients).