Experimental binding avidities of rituximab mutants to CD20 molecule
| Rituximab mutant . | KD, nM . |
|---|---|
| WT | 4.96 ± 0.21 |
| H57DE | 1.13 ± 0.07 |
| H102YT | 1.81 ± 0.09 |
| H57DE/H102YK/L93NR | 0.27 ± 0.02 |
| L93NR | 4.48 ± 0.18 |
| L93NK | 10.36 ± 0.45 |
| H57DE/H102YK | 0.31 ± 0.03 |
| Rituximab mutant . | KD, nM . |
|---|---|
| WT | 4.96 ± 0.21 |
| H57DE | 1.13 ± 0.07 |
| H102YT | 1.81 ± 0.09 |
| H57DE/H102YK/L93NR | 0.27 ± 0.02 |
| L93NR | 4.48 ± 0.18 |
| L93NK | 10.36 ± 0.45 |
| H57DE/H102YK | 0.31 ± 0.03 |
Experimental error is the SD from 3 independent experiments.
WT indicates wild-type.