Table 1 Polymorphism and frequencies of... | American Society of Hematology

Table 1

Polymorphism and frequencies of KIR2DL1 alleles

KIR2DL1 allele	Allele frequency, %	D1			D2				ST	TM	CYT		Group
KIR2DL1 allele	Allele frequency, %	15	16	99	114	154	163	182	216	245	282	312	Group
*001	11.7	G	P	I	P	P	D	H	K	R	T	T	1
*002	5.9	—	—	—	—	—	—	—	—	—	—	—	1
*00301-03	47.1	—	R	—	L	—	—	—	—	—	—	—	1
*005	0	—	R	—	L	—	—	—	—	—	—	A	1
*008	0	D	—	—	—	—	—	—	—	—	—	—	1
*009	0	—	R	—	L	—	—	—	—	—	V	—	1
*00401-02	11.7	—	R	—	—	T	N	R	E	C	—	—	2
*007	0	—	R	V	—	T	N	R	E	C	—	—	2
*006	5.9	—	R	—	L	—	—	—	—	C	—	—	3
*010	11.7	—	R	—	—	T	N	R	E	—	—	—	4

KIR2DL1 allele	Allele frequency, %	D1			D2				ST	TM	CYT		Group
KIR2DL1 allele	Allele frequency, %	15	16	99	114	154	163	182	216	245	282	312	Group
*001	11.7	G	P	I	P	P	D	H	K	R	T	T	1
*002	5.9	—	—	—	—	—	—	—	—	—	—	—	1
*00301-03	47.1	—	R	—	L	—	—	—	—	—	—	—	1
*005	0	—	R	—	L	—	—	—	—	—	—	A	1
*008	0	D	—	—	—	—	—	—	—	—	—	—	1
*009	0	—	R	—	L	—	—	—	—	—	V	—	1
*00401-02	11.7	—	R	—	—	T	N	R	E	C	—	—	2
*007	0	—	R	V	—	T	N	R	E	C	—	—	2
*006	5.9	—	R	—	L	—	—	—	—	C	—	—	3
*010	11.7	—	R	—	—	T	N	R	E	—	—	—	4

Shown is an alignment of mature KIR2DL1 alleles that distinguishes the amino acid sequences of one allele from another. Allele frequency is estimated in this study by screening 17 healthy donors. Structural domains are indicated: Ig-like domains (D1 and D2), stem domain (ST), transmembrane domain (TM), and cytoplasmic domain (CYT). The 2 × 2 combinations of amino acids in the stem and transmembrane domains categorized various alleles into 4 distinct groups.

— indicates identity with consensus to KIR2DL1*001.

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