Table 1 Comparison of the... | American Society of Hematology

Table 1

Comparison of the immunogenicities of blood group antigens obtained with corrected and traditional calculations, showing key data used in the calculation

Antigen	Total antibodies*	Antibodies reacting at 37°C and/or antiglobulin phase*	Traditional antigen potency†	Fractional persistence rate‡	Antigen potency corrected for antibody persistence§	Fold change‖
Jk^a	20	20	0.077	0.11	0.37	4.81
Lu^a	11	10	0.094	0.13	0.40	4.26
C^w	8	8	0.19	0.14	0.70	3.68
P₁	21	18	0.074	0.33	0.12	1.62
Le^b	19	18	0.062	0.37	0.089	1.44
M	18	18	0.073	0.43	0.090	1.23
Le^a	40	37	0.15	0.50	0.16	1.07
K	118	118	1.00	0.53	1.00	1.00
E	105	105	0.35	0.52	0.35	1.00
c	26	26	0.11	0.62	0.097	0.88
Fy^a	29	29	0.090	0.75	0.064	0.71
C	25	25	0.080	0.77	0.055	0.69
S	10	9	0.025	1.00	0.013	0.52
V	3	3	0.21
e	2	2	0.071
s	2	2	0.014
N	3	2	0.007
Fy^b	1	1	0.005
Jk^b	1	1	0.004

Antigen	Total antibodies*	Antibodies reacting at 37°C and/or antiglobulin phase*	Traditional antigen potency†	Fractional persistence rate‡	Antigen potency corrected for antibody persistence§	Fold change‖
Jk^a	20	20	0.077	0.11	0.37	4.81
Lu^a	11	10	0.094	0.13	0.40	4.26
C^w	8	8	0.19	0.14	0.70	3.68
P₁	21	18	0.074	0.33	0.12	1.62
Le^b	19	18	0.062	0.37	0.089	1.44
M	18	18	0.073	0.43	0.090	1.23
Le^a	40	37	0.15	0.50	0.16	1.07
K	118	118	1.00	0.53	1.00	1.00
E	105	105	0.35	0.52	0.35	1.00
c	26	26	0.11	0.62	0.097	0.88
Fy^a	29	29	0.090	0.75	0.064	0.71
C	25	25	0.080	0.77	0.055	0.69
S	10	9	0.025	1.00	0.013	0.52
V	3	3	0.21
e	2	2	0.071
s	2	2	0.014
N	3	2	0.007
Fy^b	1	1	0.005
Jk^b	1	1	0.004

Values were obtained from a previous study of this patient population.¹²

†

Calculations were based on the traditional equation of Giblett.² The potency of K was set at 1.00 and all other potencies were expressed relative to K.

‡

Fractional persistence rates represent the ratio of persistently detected antibodies of the indicated specificity to total antibodies of that specificity, as calculated in a previous study of this same patient population.⁸

Values were obtained according to the modified immunogenicity calculation presented in Figure 1B and described in ″Results and discussion.″ Blood group specificities associated with 3 or less total antibodies were excluded from the modified immunogenicity calculation due to potential errors associated with small sample size.

‖

Fold change was calculated as follows: ″Antigen potency corrected for antibody persistence″ divided by ″Traditional antigen potency.″

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