Multiple linear regression models incorporating relatives and healthy controls
| Parameter . | Coefficient (95% confidence interval) . | Contribution to variance, percentage . | P . |
|---|---|---|---|
| Clot permeability as dependent variable | |||
| Final model | 26.6 | < .001 | |
| Fibrinogen | −0.19 (−0.25 to −0.08) | 6.4 | < .001 |
| Relative (vs control) | −0.83 (−1.22 to −0.39) | 5.1 | < .001 |
| ΔAbs | −0.17 (−0.28 to −0.06) | 4.1 | < .005 |
| CRP | −1.22 (−2.35 to −0.18) | 2.5 | < .05 |
| Smoking | 0.23 (−0.20 to 0.67) | 0.6 | NS |
| Lysis time t50% as dependent variable | |||
| Final model | 30.2 | < .001 | |
| Fibrinogen | 0.86 (0.49 to 1.12) | 5.9 | < .001 |
| Relative (vs control) | 1.6 (0.68 to 2.39) | 3.9 | < .001 |
| tPA | 0.37 (0.65 to 0.27) | 3.6 | < .001 |
| CRP | 0.09 (0.01 to 0.16) | 1.8 | < .05 |
| Smoking | 0.06 (−0.23 to 0.34) | 0.6 | NS |
| Parameter . | Coefficient (95% confidence interval) . | Contribution to variance, percentage . | P . |
|---|---|---|---|
| Clot permeability as dependent variable | |||
| Final model | 26.6 | < .001 | |
| Fibrinogen | −0.19 (−0.25 to −0.08) | 6.4 | < .001 |
| Relative (vs control) | −0.83 (−1.22 to −0.39) | 5.1 | < .001 |
| ΔAbs | −0.17 (−0.28 to −0.06) | 4.1 | < .005 |
| CRP | −1.22 (−2.35 to −0.18) | 2.5 | < .05 |
| Smoking | 0.23 (−0.20 to 0.67) | 0.6 | NS |
| Lysis time t50% as dependent variable | |||
| Final model | 30.2 | < .001 | |
| Fibrinogen | 0.86 (0.49 to 1.12) | 5.9 | < .001 |
| Relative (vs control) | 1.6 (0.68 to 2.39) | 3.9 | < .001 |
| tPA | 0.37 (0.65 to 0.27) | 3.6 | < .001 |
| CRP | 0.09 (0.01 to 0.16) | 1.8 | < .05 |
| Smoking | 0.06 (−0.23 to 0.34) | 0.6 | NS |
NS indicates not significant.