Association of DARC −46C/C with disease progression in HIV+ African Americans
| . | Univariate . | Full model . | Final model . |
|---|---|---|---|
| All subjects | 0.77 (0.55-1.09) | 0.66 (0.40-1.09) | — |
| P | .146 | .102 | |
| Average WBC < 4000 | 0.33 (0.19-0.60) | 0.20 (0.07-0.60) | 0.22 (0.08-0.64) 0.005 |
| P | < .001 | .004 | |
| Average WBC ≥ 4000 | 0.84 (0.54-1.31) | 1.18 (0.62-2.27) | — |
| P | .441 | .617 |
| . | Univariate . | Full model . | Final model . |
|---|---|---|---|
| All subjects | 0.77 (0.55-1.09) | 0.66 (0.40-1.09) | — |
| P | .146 | .102 | |
| Average WBC < 4000 | 0.33 (0.19-0.60) | 0.20 (0.07-0.60) | 0.22 (0.08-0.64) 0.005 |
| P | < .001 | .004 | |
| Average WBC ≥ 4000 | 0.84 (0.54-1.31) | 1.18 (0.62-2.27) | — |
| P | .441 | .617 |
Values are relative hazards (95% confidence interval) time-to-death and P value. Covariates for the full multivariate model are baseline CD4+ T-cell count; cumulative CD4+ T-cell count (cCD4), a parameter that reflects the changes in CD4+ counts over disease course and a very strong predictor of disease progression11 ; steady-state viral load; and an admixture score derived from 11 genetic markers that was highly predictive of self-reported ethnicity (> 98% accuracy)10 and was also strongly correlated with the degree of admixture as assessed by the first principal component (obtained by EIGENSOFT program) of 96 ancestry informative markers.26 Both full model and final stepwise model have been adjusted for seroconversion and receipt of antiretroviral therapy, as defined previously.11 RH = 1 represents those with DARC −46C/T or T/T.
— indicates not retained in model.